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Addiction Boards > 2 > Flashcards

2 Flashcards

1
Q

which gene is associated with childhood adversity leading to alcohol abuse?

A

ALDH1A1

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2
Q

which gene is associated with alcohol flushing

A

GABRA6

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3
Q

which genes are associated with alcohol metabolism and linked to GI cancer

A

ADH1B and ALDH2

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4
Q

what common psychoactive drug can lead to pulmonary complications in overdose?

A

caffeine!

(phosphodiesterase inhibitor –> smooth muscle relaxation –> pulmonary edema)

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5
Q

what drug when combined with cocaine, leads to longer duration of cocaine?

A

alcohol

forms cocaethylene by transesterification

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6
Q

which class of drugs create vivid unpleasant dreams during withdrawal (in addition to mj)

A

stimulants

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7
Q

labetelol can come up as false positive for what on UDS?

A

amphetamines

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8
Q

whats the name of the syndrome where people cant get stimulation from normal daily life?

A

reward deficiency syndrome

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9
Q

whats the threshold of “at risk” drinking for adults over 65 y/o

A

more than 7 drinks a week or more than 3 drinks a night

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10
Q

incidence of heavy drinking is

A

3-9%

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11
Q

percent of older people with SUD with coocurring psychiatric illness

A

21-66%

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12
Q

papaverine (ED drug) comes up as false positive for what on UDS?

A

opiate

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13
Q

after ambulatory detox, the rate of going to residential program is

A

50%

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14
Q

are there specific rigorously tested criteria to evaluate inpatient versus outpatient detox?

A

no

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15
Q

what is mot common type of seizure induced by drugs?

A

generalized tonic clonic

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16
Q

most benzos are metabolized by

A

CYP34A oxidation and glucoronide conjugation

17
Q

lorazepam, oxazepam, and temazepam are metabolized how

A

only by conjugation

18
Q

lorazepam is metabolized to what

A

glucoronide

19
Q

how is clonazepam metabolized

A

nitroreduction

20
Q

pathway of diazepam metabolites

A

diazepam –> temazepam–> oxazepam

21
Q

is benzo metabolism affected by OCPs?

A

yes (inhibit CYP3A4)

22
Q

whats the disorder when brushing against a shirt is painful?

A

mechanical dynamic allodynia

23
Q

barbs or benzos do what to chloride channel?

A

barbs - increase duration of opening

benzos - increase frequency of opening

24
Q

which drug causes sexual dysfunction of poor erections only with substance intoxication and not withdrawal

A

amphetamines

(alcohol and opiates are both during intoxication and w/d)

25
Q

Big 5 drug test

A

opioids, amphetamines, marijuana, PCP, cocaine

26
Q

methadone is metabolized to

A

EDDP

27
Q

what is a metabolite of both heroin and codeine

A

morphine

28
Q

heroin half life and duration

A

half life - 30 min

duration - 4-5 hours (because metabolites)

29
Q

half life of codeine and oxycodone

A

Codeine - 2-3 hours

Oxycodone - 3-5 hours

30
Q

risk factors for marijuana use

A

male
teens
low SES
low education

31
Q

which gene associated with alcohol abuse and psychiatric disorders and amygdala activation?

A

SLC6A4

32
Q

which genes associated with smoking cessation and smoking relapse?

A

cessation - CHRNA5

relapse - CYP2A6

33
Q

which drugs are left out of teen drug prevention programs

A

drugs to increase athletic performance

34
Q

how do OCPs affect nicotine clearance?

A

increase clearance

35
Q

how does pregnancy affect nicotine clearance?

A

increases clearance

36
Q

are women or men more likely to seek help for gambling disorder?

A

men

37
Q

women constitute what percent of pathological gambling

A

32%

38
Q

how is meth eliminated from the body?

A

renally

39
Q

physician specialties with highest rates of SUDs

A

psychiatry
ER
anesthesia

Addiction Boards (17 decks)

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