ITP Flashcards
What is an option for a dog with Von-Willebrands Disease that needs surgery?
Give desmopressin 30 minutes prior to surgery
What’s the difference between Primary and Secondary ITP?
1: Abs bind platelets—>destruction—>severe TP
(Idiopathic, Abs target fibrinogenR, or reduction in Tregs)
2: develops due to antigenic stimulation leading to Ab formation, but it’s not without the other disease state going on
(drug, infectious dz, neoplasia)
*2ndary more common
How do we diagnose ITP?
CBC:
plt<150,000/mcL +blood smear
History taking, PE;
Platelet-bound Abs (IgG - flow cytometry) *KSU only
How do we treat ITP?
Immunosuppression; Prednisolone
Vincristine—> causes premature fragmentation of megakaryocytes!
Dosage and expectations for glucocorticoid treatment?
2mg/kg per day OR 1mg/kg BID
Usu. takes 7 days for effect
What if we have a patient in which glucocorticoids are contraindicated (i.e. diabetic, etc)?
Mycophenolate mofetil (But has some bad s/e)
How do we diagnose IMP?
Multiple joints afflicted,
Fever of unknown origin,
Neutrophili inflammation in synovial fluid,
Rule out infectious dz
What’s the difference between Non-erosive primary IMP and erosive IMP?
Non-erosive: SLE, breed (sharpeis), idiopathic (3-7 yo)
Erosive: Breed associated (greyhounds), Feline periosteal proliferating arthritis, RA (rare)
How do we identify/what do we associate with SLE?
At least 2 separate manifestations of autoimmunity AND Presence of antinuclear Abs (some patients might be negative)
Signalment for SLE in dogs vs cats?
Dogs: 3-7 years
Cats: 1-11 years
What are some common clinical signs in dogs and cats with suspected SLE?
Nonerosive polyarthritis,
Fever,
Renal disorder,
Dermatological lesions,
Lymphadenopathy/splenomegaly
In primary ITP, what are the antibodies targeted against on the platelets?
GpIIb/IIIa - the fibrinogen receptor! *reduction in Tregs*
