CRF

Question 1

What percentage of nephrons must be lost before we see azotemia?

Answer 1

75%

Question 2

What might you see on hematology and biochem in a CRF patient?

Answer 2

Nonregenerative normo-chromic/cytic anemia;
Varying K+, Ca2+;
Increased P- (sometimes)

Azotemia (increased BUN +/- Crea)—> should both increase proportionately
Decreased Alb
Metabolic acidosis

Question 3

How do we define chronic kidney disease?

Answer 3

Loss of functional renal tissue due to a prolonged process (generally >2 months); usually progressive and irreversible

Question 4

What is the first sign we will see in CKD patients?

Answer 4

PU/PD - indicating failure of urine concentration (blood panel may be normal!)

Question 5

What does the failure to synthesize calcitriol lead to?

Answer 5

Hypocalcemia and renal secondary hyperparathyroidism

Question 6

How do we get uremic gastritis with CKD?

Answer 6

The body fails to catabolize peptide hormones (e.g. gastrin)