intergument Flashcards
Integument
the largest system of the body
The integument is made up of two parts
- Cutaneous membrane (skin)
- Accessory structures
2 parts of Cutaneous Membrane
- Epidermis (superficial)
- Dermis (deep to epidermis)
what type of tissue is the epidermis (superficial)?
Epithelial tissues (ectoderm)
-> stratified squamous epithelium (keratinized0
what type of tissue is the dermis (deep to epidermis)?
- Connective tissues (mesoderm)
- Superficial = papillary layer
- Deep = reticular layer
what type of tissues is the hypodermis?
- loose connective tissue
- Superficial Fascia or Subcutaneous Layer
Accessory Structures
Originate in the dermis extend through epidermis
ex: hair, nails, exocrine glands
function of integument
- protect (physical & chemically)
- thermoregulation
- immune defense
- water resistance
- metabolic regulation
- storage
- sensory
what is the function of integument help in metabolic regulation of body?
vitamin D3 production
specialized cells within epidermis
- keratinocytes
- melanocytes
- dendritic cells
- Markel cells
what type of cells is most abundant in epidermis to produce keratin?
keratinocyte
which types of specialized cell in epidermis create melanin?
melanocytes
which type of specialized cell in epidermis produce immune system?
dendritic (Langerhans cells)
which type of specialized cell in epidermis related to nervous system, detect touch/pressure?
Merkel cells
2 types of skin
- thin skin
- thick skin
thin skin
–Covers most of the body
–Has four layers of keratinocytes
thick skin
–Covers the palms of the hands and soles of the feet
–Has five layers of keratinocytes
five strata of keratinocytes (from basal lamina (deep) to free surface (superficial) )
- Stratum basale
- Stratum spinosum
- Stratum granulosum
- Stratum lucidum*
- Stratum corneum
structure of stratum basale
- epidermal ridges (form fingerprint)
- dermal papillae
- many basal cells
- melanocytes
where does mitosis begin in stratum basale?
basal cells (germinative cells)
Stratum Spinosum
- continue to divide -> increase thickness of epithelium
- contain dendritic cells
Stratum Granulosum
–Cells stop dividing
–Start producing: Keratin and Keratohyalin
-eventually cells die
Stratum Lucidum
- “clear layer”
- Found only in thick skin
- Covers stratum granulosum
- 3-5 layers of dead keratinocytes
Stratum Corneum
-the “horn layer”
* Exposed surface of skin
* 15 to 30 layers of dead keratinized cells
* Water resistant
* Shed and replaced every 2 weeks
Keratinization (cornification)
The formation of a layer of dead, protective cells
filled with keratin
what surface do not get keratinization?
eyes
how long does it take for keratinized stratum basale to stratum corneum?
15- 30 days
two types of pigment influence skin color
- Carotene
- Melanin
Carotene
–Orange-yellow pigment
–Found in orange vegetables
–Nonpolar
–Converted to vitamin A
Melanin
–Yellow-brown or black pigment
–Produced by melanocytes in stratum basale
–Stored in vesicles - melanosomes
–Keratinocytes incorporate by endocytosis
Function of Melanocytes
Melanin protects skin from sun damage
consequence of UV radiation
Causes DNA mutations and burns that lead to cancer
and wrinkles
Skin color depends on ________ __________, not
number of melanocytes
melanin production
disease caused by UV damage
Actinic keratosis – scaley sun damaged areas
skin cancers
–Basal cell carcinoma – #1
–Squamous cell carcinoma – #2
–Malignant melanoma – cancerous melanocyte
Blood contributes to skin color (conditions)
- erythema
- cyanosis
- pallor
- hematoma
Erythema
blush/flush, reddish
cyanosis
low oxygenated blood, bluish tint
pallor
Pale, low blood flow to skin