Inflammation

Question 1

What 4 classes of drugs can be used to treat inflamamtion?

Answer 1

Glucocorticoids
NSAIDS
Anti-TNF alphas
Immunosuppressants

Question 2

What are 3 side effects of glucocorticoids?

Answer 2

Iatrogenic cushings, thinning of skin (dyslipotrophy), salt and water retension, immunosuppression, decreased osteoblast activity

Question 3

What does infliximab do?

Answer 3

Prevent TNFa from binding to receptors targeting antibodies and cytokine

Question 4

What drug is infliximab often used with?

Answer 4

Methotrexate

Question 5

Name 3 immunosuppresants

Answer 5

Azathioprine
Cyclosporin
Methotrexate

Question 6

What is azathioprine used for?

Answer 6

Rheumatoid arthritis

Crohns disease

Question 7

What is cyclosporin used for?

Answer 7

Rheumatoid arthritis

Organ donation immune suppression

Question 8

What is the mechanism behind cyclosporin

Answer 8

Inhibits production and release of lymphokins

Question 9

What are side effects of cyclosporin?

Answer 9

Headarche, Hypertrichosis, acne

Question 10

What is diclofenac and name 4 other drugs that are in its class?

Answer 10

It is a non-steroidal anti-inflammatory
Ibuprofen 
Aspirin 
Paracetamol 
Naproxin

Question 11

How do NSAIDS work

Answer 11

COX II cyclooxygenase inhibitors that prevent the formation of prostaglandins

Question 12

What are side effect of NSAD?

Answer 12

anti-pyretic, peptic ulcers