inflammation Flashcards
what is inflammation
a reaction/response to injury or infection involving cells such as neutrophils and macrophages
when is inflammation good
infection
injury
inflammatory process fights off infection and repairs injuries
when is inflammation bad
autoimmunity
when it is an over reaction to the stimulus
how is inflammation good like what does it do
Destruction of invading microorganisms and the walling off of an abscess cavity thereby preventing the spread of infection
two types of inflammation
acute
chronic
describe acute inflammation
sudden onset
short duration
usually resolves
describe chronic inflammation
slow onset or sequel to acute
long duration
may never resolve
what cells are involved in inflammation (5)
neutrophil polymorphs
macrophages
lymphocytes
endothelial cells
fibroblasts
main cell in acute inflammation
neutrophils
main cell in chronic inflammation
macrophages and lymphocytes
what are neutrophils
mobile bags of enzymes with vesicles that contain enzymes to kill things
move around and latch onto things and then release enzymes
describe neutrophil polymorphs
short lived
first on the scene of acute inflammation
cytoplasmic granules full of enzymes that kill bacteria
usually die on the scene of inflammation
release chemicals that attract other inflammatory cells such as macrophages
describe macrophages
long lived cells (weeks to months)
phagocytic properties
ingest bacteria and debris
may carry debris away
may present antigen to lymphocytes
describe lymphocytes
long lived cells (years)
produce chemicals which attract in other inflammatory cells
immunological memory for past infections and antigens
describe endothelial cells
line capillary blood vessels in areas of inflammation
become sticky in areas of inflammation so inflammatory cells can stick to them
become porous to allow inflammatory cells to pass into tissues
grow into areas of damage to form new capillary vessels
describe fibroblasts
long lived cells
form collagen in areas of chronic inflammation and repair
describe acute appendicitis
unknown precipitating factor
neutrophils appear
blood vessels dilate
inflammation of serosal surface occurs
pain felt
appendix either surgically removed or inflammation resolves or appendix bursts with generalised peritonitis and possible death