allergy and hypersensitivity

Question 1

define type 1 hypersensitivity

Answer 1

an immediate reaction to environmental antigens mediated via IgE

Question 2

what is an inherited trait for type I hypersensitivity

Answer 2

atopy

Question 3

what are allergens

Answer 3

antigens that trigger allergic reactions

Question 4

Process of allergic reaction

Answer 4

1. body exposed to allergen, mostly skin, GI tract, lungs
2. allergens that make it through physical barrier taken up by APC, presented to naive T cells
3. naive T cell becomes Th2
4. interleukin 4, 13 activates B cells
5. B cell produce IgE which can bind to allergen