carcinogenesis Flashcards
define carcinogenesis
the transformation of normal cells to neoplastic cells through permanent genetic alterations or mutations
what does carcinogenesis apply to
malignant neoplasms
define oncogenesis
the development of benign and malignant tumours
is carcinogenesis a multi step or one step process
multi step
define carcinogens
Agents known or suspected to cause tumours
define carcinogenic
cancer causing
define oncogenic
tumour causing
why are carcinogens mutagenic
they act on DNA
which cancer has smoking got a strong incidence with
lung cancer
what does bladder cancer have an increased incidence in
increased incidence in aniline dye and rubber industries
what does scrotal cancer have an increased incidence in
chimney sweeps
What are the 5 classes of carcinogens
chemical
viral
ionising and non ionising
hormones, parasites and mycotoxins
miscalenneous
describe chemical carcinogens
no common structural features
some act directly
most require metabolic conversation from pro-carcinogens to ultimate carcinogens
enzyme required may be ubiquitous or confined to certain organs
describe Ionising and non-ionising radiation
Exposure to UVA or UVB
Ionising radiation
Long term effect
impact of radiation on radiographers
skin cancer