carcinogenesis Flashcards

1
Q

define carcinogenesis

A

the transformation of normal cells to neoplastic cells through permanent genetic alterations or mutations

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2
Q

what does carcinogenesis apply to

A

malignant neoplasms

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3
Q

define oncogenesis

A

the development of benign and malignant tumours

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4
Q

is carcinogenesis a multi step or one step process

A

multi step

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5
Q

define carcinogens

A

Agents known or suspected to cause tumours

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6
Q

define carcinogenic

A

cancer causing

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7
Q

define oncogenic

A

tumour causing

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8
Q

why are carcinogens mutagenic

A

they act on DNA

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9
Q

which cancer has smoking got a strong incidence with

A

lung cancer

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10
Q

what does bladder cancer have an increased incidence in

A

increased incidence in aniline dye and rubber industries

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11
Q

what does scrotal cancer have an increased incidence in

A

chimney sweeps

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12
Q

What are the 5 classes of carcinogens

A

chemical
viral
ionising and non ionising
hormones, parasites and mycotoxins
miscalenneous

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13
Q

describe chemical carcinogens

A

no common structural features
some act directly
most require metabolic conversation from pro-carcinogens to ultimate carcinogens
enzyme required may be ubiquitous or confined to certain organs

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14
Q

describe Ionising and non-ionising radiation

A

Exposure to UVA or UVB
Ionising radiation
Long term effect

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15
Q

impact of radiation on radiographers

A

skin cancer

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16
Q

impact of radiation on uranium miners

A

lung cancer

17
Q

impact of radiation on ukranian children

A

thyroid cancer

18
Q

what percent of cancer risks are inherited

A

15%

19
Q

define host factor

A

the traits of an individual person or animal that affect susceptibility to disease

20
Q

give 5 host factors for carcinogenesis

A

race
diet
constitutional factors - age, gender
premalignant conditions
transplacental exposure

21
Q

impact of race on skin cancer

A

decreased skin cancer in black people due to melanin

22
Q

impact of race on oral cancer

A

Increased oral cancer in India, SE Asia due to reverse smoking

23
Q

impact of age on cancer

A

incidence increases with age

24
Q

impact of Premalignant conditions
on cancer

A

Identifiable local abnormality associated with increased risk of malignancy at that site e.g. colonic polyps, undescended testis, cervical dysplasia

25
Q

what cancers does alcohol increase risk of

A

mouth
oesophagus
liver
colon
breast

26
Q

what cancers does obesity increase the risk of

A

breast
oesophagus
colon
kidney

27
Q

what cancers does exercise reduce the risk of

A

colon
breast

28
Q

what does unprotected sex increase risk of

A

HPV related cancer
(cervix, penis, oesophagus)

29
Q
A