Inflammation Flashcards

1
Q

What is not a role of the immune system
- maintain electrolyte balance
- disease protection
- detection of pathogens and immunogens
- differentiate self vs not

A

not electrolytes

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2
Q

pathogen

A

virus or bacteria

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3
Q

immunogen

A

pathogen, tumor, allergen

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4
Q

Innate immunity:
acquired/natural
non-adaptive/specific
fast acting/slow
long-lived/robust

A

natural, nonadaptive, fast acting and robust

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5
Q

physical innate immune system

A

skin and mucosal linings

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6
Q

which is not a part of the chemical innate immune system
- pH
- compliment system
- mucosal linings
- acute phase proteins

A

not mucosal linings
SIDE NOTE: complement system (proteins that help antibodies and phagocytes), acute phase proteins (humoral, mediate inflammation)

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7
Q

what cell mediates innate inflammation

A

Leukocytes (WBC)

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8
Q

What cells contribute to inflammation

A

mast cells, phagocytes –> macrophages, NKs, dendritic cells

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9
Q

adaptive immunity:
acquired/natural
specific/non-adaptive
fast acting/slow
robust/long lived

A

acquired, specific, slow and long-lived

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10
Q

Which one is not a part of humoral adaptive immunity
- antibodies
- memory
- B-cells
- skin

A

Skin is innate, not humoral

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11
Q

Cell-mediated adaptive immunity consists of what cells?

A

T-cells (toxic), B-cells (create antibodies)

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12
Q

What is required for cell-mediated adaptive immunity

A

lymphocytes or cells

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13
Q

which immune system is specific to the antigen

A

adaptive

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14
Q

which immune system creates cytokines

A

both innate and adaptive

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15
Q

which immune system has cell-mediated inflammation

A

innate

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16
Q

which immune system uses skin, pH and NKs

17
Q

which immune system uses B-cells and T-cells

18
Q

what do viruses need to replicate

A

a living cell

19
Q

what do vaccines do

A

prepare immune system, preventing severity

20
Q

what do boosters do

A

remind B-cells of anitobodies

21
Q

adverse event

A

a medical occurrence in a clinical trial, not necessarily causal

22
Q

immunocompromised

A

immune system takes longer to fight off pathogens and immunogens

23
Q

cytokines

A

polypeptides involved in communication, regulate cellular function

24
Q

what is not one of the 3 major classes of cytokines
- immunogens
- interleukins
- interferons
- TNF

A
  • immunogens
25
interleukins
mediate inflammation, regulate immune function
26
interferons
interfere with replication of viruses
27
tumor necrosis factor (TNF)
mediates responses
28
immunosenescence
age related changes in the immune system
29
inflammaging
consistent low grade inflammation
30
is inflammaging: progressive/sudden chronic/temporary clinical/subclinical
progressive, chronic and sub-clinical
31
how does immunosenescence affect coping with stressors
overall decrease in ability to cope
32
immunosenescence does not increase the risk of what diseases? - alzheimer's and dementia - diabetes and MS - frailty and sarcopenia - OP and OA
not MS and not OA
33
are pro or anti-inflammatory cytokines produced more?
Pro
34
is innate or adaptive immunity compromised with age?
adaptive, which leads to overuse of innate immunity and increased inflammation
35
which of the following increases with age? - disease-fighting ability - wound repair - auto-immunity - innate immunity
auto-immunity