Epigenetics Flashcards
epigenetics
way of modifying DNA without changing sequencing (how much or what is expressed)
which is not a type of DNA mod
- DNA myelination
- histone modification
- base pair rebinding
- chromatin remodeling
- no base pair change
what are the effects of DNA mods on chromatin and DNA
affects chromatin structure, therefor DNA accessibility
how does methyl effect chromatin
inactivates chromatin
What happens to global DNAm with age
decreases, but specific regions of DNA increase
epigenetic drift
decrease in DNAm in regions that had high DNAm (and vice versa)
how does HIIT affect DNAm
immediately decreases DNAm but increase in fat cells after 6 months of training
Which environmental factor does not affect epigenetics
- diet
- nutrition
- weight
- actvity
weight
epigenetic clock
amount of modification to DNA
Is DNAm tissue independent or tissue specific?
both
What predicts chronological age within 2 years?
DNAm
epigenetic age acceleration
when DNA appears older than you