Infectious Disease -- STDs

Question 1

Name the organism in Chlamydia

Answer 1

C. trachomatis

Question 2

Most Chlamydia cases are reported in which gender?

Answer 2

Women

Question 3

Three causes of non-gonococcal urethritis

Answer 3

Chlamydia
Mycoplasma hominis
Mycoplasma genitalium

Question 4

How is Chlamydia visualized?

Answer 4

It is intracellular, so look in the vacuoles with a Giemsa stain

Question 5

Two forms of chlamydia

Answer 5

Elementary Bodies – Infectious Form

Reticulate Bodies – Replicative Form

Question 6

Chlamydia has serotypes…

Answer 6

D thru K

Question 7

Histology seen in Chlamydia infection

Answer 7

Inclusions in epithelial cells

Chronic Immune Response to intracelluar infection is an important component of disease

Question 8

Chlamydia is associated with enhanced transmission of ______

Answer 8

AIDS

Question 9

Pathology of Chlamydia

Answer 9

Epididymitis, prostatitis, PID, pharyngitis, proctitis

Virtually identical to Gonorr. except discharge

Question 10

Describe the discharge from a chlamydia patient

Answer 10

Mucopurulent

No organisms visible

Question 11

Self-limited suppurative conjunctivitis can be cased by Chlamydia exposure in….

Answer 11

Birth Canal

Swimming Pool

Question 12

What is Trachoma?

Answer 12

Chronic Suppurative keratoconjunctivitis causing blindness in many parts of the world. This can even spread by direct contact in under-developed nations

Question 13

What is Lymphogranuloma Venereum in Chlamydia?

Answer 13

A suppurative infection of regional lymph nodes with buboe formation.

Question 14

Complication of Lymphogranuloma Venereum?

Answer 14

Rectal stricture

Question 15

Describe the development of Lymphogranuloma Venereum.

Answer 15

Chronic, ulcerative disease w/ involvement of LN
Begins w/ small papule
Growth of organism and host response result in swollen, tender, draining LN
Stellate abscesses
Potentially fibrosis and anal strictures

Question 16

What are stellate abscesses

Answer 16

Mixed granulomatous and neutrophilic inflammation

Question 17

How to treat Chlamydia?

Answer 17

1g Azithromycin orally in a single dose

100 mg doxyorally BID for 7 days

Question 18

What matters about C. pneumoniae?

Answer 18

Cause of URT and pneumonia in adults
Associated with Atherosclerotic vascular disease
Possible co-factor in atherosclerosis development

Question 19

What matters about C. psittaci?

Answer 19

Rare “Atypical pneumonia” transmitted from birds

Question 20

In men, gonorrhea urethritis can spread to involve…

Answer 20

Seminal vesicles

Chronic –> urethral strictures, sterility

Question 21

What is granuloma inguinale?

Answer 21

A Chronic, Venerally transmitted disease with ulcerating and granulating lesions of the genital skin and mucosa

Question 22

What causes granuloma inguinale?

Answer 22

Calymmatobacterium donvoni

Question 23

Hemophilus ducreyi is assocaited with what other illnesses

Answer 23

Ulcers facilitate HIV transmission

Question 24

Trichomoniasis is typically caused by…

Answer 24

Trichomonas vaginalis

A protazoan which causes superficial lesions of urethral surfaces

Question 25

Symptoms of Trichomoniasis?

Answer 25

Men -- Non-gonococcaal urethritis | Women -- Itching, Profuse, watery vaginal discharge

Question 26

On physical exam of Trichomoniasis patient, what does the affected mucosa show

Answer 26

Stawberry Mucosa -- Small blisters or papules

Question 27

Syphilis chancres are infiltrated with what immune cell?

Answer 27

TH1

Question 28

______ is central to the pathology of all Syphilis

Answer 28

Endarteritis

Question 29

Describe the infiltrate found at site of spirochete invasion

Answer 29

Lymphoplasmacytic

Question 30

Describe what happens in primary syphilis obliterative endarteritis

Answer 30

Vessel wall infiltrates Endothelial proliferation Intimal fibrosis

Question 31

Difference between condylomata lata and condylomata accuminata?

Answer 31

lata -- syphilis -- elevated broad plaques | accuminate -- venereal warts

Question 32

Do secondary syphilis lesions hurt?

Answer 32

Nope

Question 33

Describe cardiovascular syphilis

Answer 33

Damage to proximal aorta/aortic root Obliterative endarteritis -- tree barking Aneurysms and dissections Coronary Insufficiency

Question 34

Syphilitic gummas tend to be found...

Answer 34

Skin Liver Bones Testes

Question 35

Describe a syphilitic gumma

Answer 35

Peculiar rubbery, gummatous necrosis

Question 36

Describe the histology of a syphilitic gumma

Answer 36

Central necrotic debris surrounded by palisading macrophages+fibroblasts Surr. by mononuclear leukocytes (mostly plasma cells)

Question 37

Which stage of syphilis is most assocaited with congenital syph?

Answer 37

secondary

Question 38

What is Hutchison's Triad?

Answer 38

Hutchison's Teeth Interstitial keratitis CN8 deafness