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Pathology -- Infectious Disease > Infectious Disease -- STDs > Flashcards

Infectious Disease -- STDs Flashcards

1
Q

Name the organism in Chlamydia

A

C. trachomatis

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2
Q

Most Chlamydia cases are reported in which gender?

A

Women

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3
Q

Three causes of non-gonococcal urethritis

A

Chlamydia
Mycoplasma hominis
Mycoplasma genitalium

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4
Q

How is Chlamydia visualized?

A

It is intracellular, so look in the vacuoles with a Giemsa stain

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5
Q

Two forms of chlamydia

A

Elementary Bodies – Infectious Form

Reticulate Bodies – Replicative Form

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6
Q

Chlamydia has serotypes…

A

D thru K

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7
Q

Histology seen in Chlamydia infection

A

Inclusions in epithelial cells

Chronic Immune Response to intracelluar infection is an important component of disease

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8
Q

Chlamydia is associated with enhanced transmission of ______

A

AIDS

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9
Q

Pathology of Chlamydia

A

Epididymitis, prostatitis, PID, pharyngitis, proctitis

Virtually identical to Gonorr. except discharge

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10
Q

Describe the discharge from a chlamydia patient

A

Mucopurulent

No organisms visible

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11
Q

Self-limited suppurative conjunctivitis can be cased by Chlamydia exposure in….

A

Birth Canal

Swimming Pool

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12
Q

What is Trachoma?

A

Chronic Suppurative keratoconjunctivitis causing blindness in many parts of the world. This can even spread by direct contact in under-developed nations

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13
Q

What is Lymphogranuloma Venereum in Chlamydia?

A

A suppurative infection of regional lymph nodes with buboe formation.

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14
Q

Complication of Lymphogranuloma Venereum?

A

Rectal stricture

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15
Q

Describe the development of Lymphogranuloma Venereum.

A

Chronic, ulcerative disease w/ involvement of LN
Begins w/ small papule
Growth of organism and host response result in swollen, tender, draining LN
Stellate abscesses
Potentially fibrosis and anal strictures

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16
Q

What are stellate abscesses

A

Mixed granulomatous and neutrophilic inflammation

17
Q

How to treat Chlamydia?

A

1g Azithromycin orally in a single dose

100 mg doxyorally BID for 7 days

18
Q

What matters about C. pneumoniae?

A

Cause of URT and pneumonia in adults
Associated with Atherosclerotic vascular disease
Possible co-factor in atherosclerosis development

19
Q

What matters about C. psittaci?

A

Rare “Atypical pneumonia” transmitted from birds

20
Q

In men, gonorrhea urethritis can spread to involve…

A

Seminal vesicles

Chronic –> urethral strictures, sterility

21
Q

What is granuloma inguinale?

A

A Chronic, Venerally transmitted disease with ulcerating and granulating lesions of the genital skin and mucosa

22
Q

What causes granuloma inguinale?

A

Calymmatobacterium donvoni

23
Q

Hemophilus ducreyi is assocaited with what other illnesses

A

Ulcers facilitate HIV transmission

24
Q

Trichomoniasis is typically caused by…

A

Trichomonas vaginalis

A protazoan which causes superficial lesions of urethral surfaces

25
Q

Symptoms of Trichomoniasis?

A

Men – Non-gonococcaal urethritis

Women – Itching, Profuse, watery vaginal discharge

26
Q

On physical exam of Trichomoniasis patient, what does the affected mucosa show

A

Stawberry Mucosa – Small blisters or papules

27
Q

Syphilis chancres are infiltrated with what immune cell?

A

TH1

28
Q

______ is central to the pathology of all Syphilis

A

Endarteritis

29
Q

Describe the infiltrate found at site of spirochete invasion

A

Lymphoplasmacytic

30
Q

Describe what happens in primary syphilis obliterative endarteritis

A

Vessel wall infiltrates
Endothelial proliferation
Intimal fibrosis

31
Q

Difference between condylomata lata and condylomata accuminata?

A

lata – syphilis – elevated broad plaques

accuminate – venereal warts

32
Q

Do secondary syphilis lesions hurt?

A

Nope

33
Q

Describe cardiovascular syphilis

A

Damage to proximal aorta/aortic root
Obliterative endarteritis – tree barking
Aneurysms and dissections
Coronary Insufficiency

34
Q

Syphilitic gummas tend to be found…

A

Skin
Liver
Bones
Testes

35
Q

Describe a syphilitic gumma

A

Peculiar rubbery, gummatous necrosis

36
Q

Describe the histology of a syphilitic gumma

A

Central necrotic debris
surrounded by palisading macrophages+fibroblasts
Surr. by mononuclear leukocytes (mostly plasma cells)

37
Q

Which stage of syphilis is most assocaited with congenital syph?

A

secondary

38
Q

What is Hutchison’s Triad?

A

Hutchison’s Teeth
Interstitial keratitis
CN8 deafness

Pathology -- Infectious Disease (23 decks)

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