Infectious Disease -- Bacteria III -- Packet Additions Flashcards
Mechanism for Cholera?
Toxin subunit A binds with ADP ribosylation factors to activate GTP-activated adenylate cyclase. This results in cAMP formation. cAMP stimulates the secretion of chloride and bicarbonate.
Explain why traveler’s diarrhea happens in a foreign country?
Diff antigens than home?
Pathogenesis of E. coli O157:H7
Cause of hemolysis?
Cause of uremia?
Shiga/Vero toxin
Obstruction of glomeruli by microthrombi
Why is processed hamburger most associated with E Coli O157:H7 outbreak?
Cattle don’t have a receptor for Shiga toxin, so they can harbor a lot of bacteria without symptoms. When cattle are butchered, they are all mixed up together, so many hamburgers may include the one, asymptomatic but very infected cow.
How is typhoid fever different from other forms of enteritis
Pathogenesis relies on invasion, bacteremia, and distant tissue colonization
Incubation period for Typhoid Fever
1-2 Weeks
Three types of enteritis from undercooked foods
Salmonella, Campylobacter, C Perfringens (serve withut reheating)
Three types of enteritis from fecal oral
E Coli, Shigella, Cholera
Two forms of enteritis from contamination of stored foods
Salmonella, Botulisim
Three diseases associated with a day care setting
Shigella, E Coli
Rotavirus
Giardia, Cryptosporidium
Progression of Typhoid Fever by week
1 - Fever, chills, bacteremia
2 - Widespread mononuclear phagocytic involvement with rash
3 - Oval plaques on Peyer’s patches (which later ulcerate)
Most common cause of gastritis, diarrhea, and dysentery in the US
Campylobacter
Bold letter pathogenic symptom of Campylobacter infection
Foul-smelling stools with blood or exudate
Relative Frequency of Sa, Sh, Ca, and Typhoid Fever?
Campylobacter
Salmonella
Shigella
Typhoid Fever
Two antibiotics assocaited with C diff
Clindamycin
Lincomycin
