Infectious Disease -- Bacteria IV -- Packet Additions

Question 1

Typhus fatalities increase with which mutation

Answer 1

G6PD deficiency

Question 2

How long will a RMSF Fever last for

Answer 2

2-3 weeks

Question 3

What specific tick transmits Lyme Disease

Answer 3

Tick of the White Tailed Deer

Question 4

Molecularly speaking – cause of most Lyme Disease symptoms

Answer 4

Binding of Bacterial LPS to TLR2 of macrophages

Question 5

Three morphology components seen in Lyme

Answer 5

Lymphoplasmacytic infiltrates
Synovial hyperplasia with lymphocytes and plasma cells
Onion-skin arteritis

Question 6

What is a sylvatic cycle

Answer 6

Man is an accidental victim of cycle where an organism spreads among wild animals

Question 7

How do people get Tularemia?

Answer 7

Contact with rabbits or rabbit skin

Direct contamination of skin/conjunctiva by organism

Question 8

Three forms of Tularemia?

Answer 8

Ulceroglandular Tularemia
1 or 2 pulmonary infection with hilar lymphadenopathy
Oculoglandular

Question 9

What happens in ulceroglandular Tularemia?

Answer 9

Local skin lesion,
Ulcerated Pustule,
enlargement of LN,
Bacteremic Phase

Question 10

Pathologic mechanism of Tularemia?

Answer 10

Purulent necrosis and granulomatous reactions

Leukocytosis not striking

Question 11

Tularemia fatalities (1-6%) are associated with…

Answer 11

endotoxin like reactions

Question 12

Bacterial Pet-Related Diseases Include…

Answer 12

Pasturella multocida
Cat Scratch (Bartonella henselae)
Ornithosis (Chlamydia psittaci)
Salmonellosis

Question 13

How do people get Pasturella multocida?

Answer 13

Animal Bites, Scratches (esp Cats)

Question 14

Symptoms of Pasturella multocida infection

Answer 14

Rapidly developing cellulitis, abscesses, sepsis

Question 15

Treatment for animal bites in response to Pasturella multocida?

Answer 15

Augmentin

Question 16

Symptoms of Bartonella henslae?

Answer 16

Possibly Asymptomatic

Localized Lymphadenopathy

Question 17

Who gets Bartonella henslae?

Answer 17

Mainly young children

Question 18

What happens when an AIDS patient gets Bartonella henslae?

Answer 18

Bacillary angiomatosis

Question 19

Ornithosis is caused by….

Answer 19

Chlamydia psittaci

Question 20

How do you get infected with Chlamydia psittaci?

Answer 20

Inhalation of dust-borne excreta from birds

Question 21

Symptoms of Chlamydia psittaci?

Answer 21

Pneumonia (May involve severe dyspnea without other signs)
Interstitial inflammation with edema, hyperemia, mononuc. infiltrate
Lethal Generalized disease

Question 22

Hallmarks of Chlamydia psittaci lethal generalized disease

Answer 22

Focal necrosis in the liver + Spleen

Diffuse mononuclear infiltrative changes in kidneys, heart, and brain

Question 23

Salmonellosis is caused by which pets?

Answer 23

Turtles, Reptiles

Question 24

Toxoplasmosa gondii is what type of microbe?

Answer 24

Obligate Intracellular Protazoan

Question 25

Effects of Toxoplasmosa gondii in a normal person?

Answer 25

Subclinical infection or mild lymphadenopathy

Question 26

Toxoplasmosa gondii is spread how (usually)?

Answer 26

Reproduces in cat intestinal epithelium Shed in feces Oocytes mature in 24 hours

Question 27

Toxoplasmosa gondii in mom's first trimester leads to...

Answer 27

Severe disseminated infection Fatality rate of 25% Transplacental Transmission

Question 28

Toxoplasmosa gondii in mom's third trimester leads to...

Answer 28

Chorioretinitis/Blindness

Question 29

Toxoplasmosa gondii in AIDS patients leads to....

Answer 29

Encephalitis

Question 30

Pathogenesis of Toxoplasmosa gondii in normal person?

Answer 30

Can infect all cell types by binding laminin receptors | Lymphoid Hyperplasia

Question 31

Pathogenesis of Toxoplasmosa gondii in IC and neonates?

Answer 31

Extensive destruction of the CNS, Liver, Heart, Lungs, Adrenals

Question 32

What can Toxoplasmosa gondii do in AIDS patients (other than swell the brain)

Answer 32

Reactivate a latent infection

Question 33

Leptospirosis symptoms in mild disease

Answer 33

Acute, self limited, febrile illness Biphasic Fever and meningeal irritation Conjunctival irritation and hyperemia

Question 34

How is Leptospirosis transmitted?

Answer 34

Excreted in dog urine | Also transmitted in water contaminated with animal products

Question 35

More severe Leptospirosis symptoms?

Answer 35

Lymphocytic atypical meningitis: severe Leptospirosis with jaundice, bleeding, and renal failure (Weil's Disease)

Question 36

Pathogenesis of Leptospirosis?

Answer 36

Leptospirae disseminate through liver, spleen, kidneys, CNS with minimal cellular rxn Lymphocytes appear in immune phase Looks like viral meningitis

Question 37

How do people get Rabies?

Answer 37

Wild dogs cause to most cases worldwide | In US -- mostly bats, some raccoons, foxes, skunks, and coyotes

Question 38

Rabies is histologically identified by...

Answer 38

Negrii bodies in nerve cells

Question 39

How is Rabies diagnosed?

Answer 39

Direct examination of brain tissue from an infected animal

Question 40

How is Rabies treated?

Answer 40

gamma globulin

Question 41

Three diseases primarily assocaited with Cats

Answer 41

Pasteruella multocida Cat-Scratch (Bartonella) Toxoplasmosis

Question 42

Two primarily dog related diseases?

Answer 42

Leptospirosis | Rabies

Question 43

Lymphocytic choriomeningitis virus is carried by

Answer 43

Hamsters and other pocket pets

Question 44

pathologic mechanism of anthrax?

Answer 44

Antiphagocytic activity, Edema Factor, Cytotoxic Factor Infections associated with leukopenia Can cause meningitis, electrolyte imbalane Death by DIC

Question 45

How to treat anthrax?

Answer 45

Penicillin | Doxy

Question 46

Listeria monocytogenes method of transmission?

Answer 46

- Contact with infected abortion, stillbirth, or neonatal sepsis from infected animals - Unpasteurized Milk and Milk Products - Contaminated Silage, forage - Vaginally during childbirth

Question 47

Forms of Listeria monocytogenes

Answer 47

Abortion (amnionitis) Neonatal Sepsis Meningitis (in IC adults)

Question 48

How is Brucellosis transmitted?

Answer 48

Contact with infected tissues Unpasteurized milk and milk Products Occupational exposure for vets/meat workers

Question 49

Forms of Brucellosis?

Answer 49

1. Symmetrical bacterial disease with bacteremia, fever granulomatous inflammation of lymphoreticular system --> hepatosplenomegaly 2. Rarely, pneumonias

Question 50

Pathologic mechanisms of Brucellosis?

Answer 50

Intracellular habitat and macrophage activation

Question 51

How is Q Fever transmitted?

Answer 51

By Tick

Question 52

Symptoms of Q Fever?

Answer 52

Headache, Cough, Myalgia, Lymphadenopathy, hepatosplenomegaly 2. Rare pneumonias

Question 53

Mechanism of Q Fever?

Answer 53

Nonspecific Necrosis Mononuclear Infiltrates Fibrin Exudates

Question 54

What are Glanders and Melioidosis caused by?

Answer 54

Pseudomonas mallei and pseudomallei

Question 55

Glanders and Melioidosis animal reservoirs?

Answer 55

Horses, Donkeys, Mules

Question 56

Glanders and Melioidosis symptoms

Answer 56

``` Local papular abscess Regional lymph nodes Satellite, Pyemic Abscesses Bacteremia Fatal Lung Involvement ```