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Pathology -- Infectious Disease > Infectious Disease -- Bacteria IV -- Packet Additions > Flashcards

Infectious Disease -- Bacteria IV -- Packet Additions Flashcards

1
Q

Typhus fatalities increase with which mutation

A

G6PD deficiency

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2
Q

How long will a RMSF Fever last for

A

2-3 weeks

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3
Q

What specific tick transmits Lyme Disease

A

Tick of the White Tailed Deer

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4
Q

Molecularly speaking – cause of most Lyme Disease symptoms

A

Binding of Bacterial LPS to TLR2 of macrophages

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5
Q

Three morphology components seen in Lyme

A

Lymphoplasmacytic infiltrates
Synovial hyperplasia with lymphocytes and plasma cells
Onion-skin arteritis

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6
Q

What is a sylvatic cycle

A

Man is an accidental victim of cycle where an organism spreads among wild animals

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7
Q

How do people get Tularemia?

A

Contact with rabbits or rabbit skin

Direct contamination of skin/conjunctiva by organism

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8
Q

Three forms of Tularemia?

A

Ulceroglandular Tularemia
1 or 2 pulmonary infection with hilar lymphadenopathy
Oculoglandular

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9
Q

What happens in ulceroglandular Tularemia?

A

Local skin lesion,
Ulcerated Pustule,
enlargement of LN,
Bacteremic Phase

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10
Q

Pathologic mechanism of Tularemia?

A

Purulent necrosis and granulomatous reactions

Leukocytosis not striking

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11
Q

Tularemia fatalities (1-6%) are associated with…

A

endotoxin like reactions

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12
Q

Bacterial Pet-Related Diseases Include…

A

Pasturella multocida
Cat Scratch (Bartonella henselae)
Ornithosis (Chlamydia psittaci)
Salmonellosis

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13
Q

How do people get Pasturella multocida?

A

Animal Bites, Scratches (esp Cats)

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14
Q

Symptoms of Pasturella multocida infection

A

Rapidly developing cellulitis, abscesses, sepsis

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15
Q

Treatment for animal bites in response to Pasturella multocida?

A

Augmentin

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16
Q

Symptoms of Bartonella henslae?

A

Possibly Asymptomatic

Localized Lymphadenopathy

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17
Q

Who gets Bartonella henslae?

A

Mainly young children

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18
Q

What happens when an AIDS patient gets Bartonella henslae?

A

Bacillary angiomatosis

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19
Q

Ornithosis is caused by….

A

Chlamydia psittaci

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20
Q

How do you get infected with Chlamydia psittaci?

A

Inhalation of dust-borne excreta from birds

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21
Q

Symptoms of Chlamydia psittaci?

A

Pneumonia (May involve severe dyspnea without other signs)
Interstitial inflammation with edema, hyperemia, mononuc. infiltrate
Lethal Generalized disease

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22
Q

Hallmarks of Chlamydia psittaci lethal generalized disease

A

Focal necrosis in the liver + Spleen

Diffuse mononuclear infiltrative changes in kidneys, heart, and brain

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23
Q

Salmonellosis is caused by which pets?

A

Turtles, Reptiles

24
Q

Toxoplasmosa gondii is what type of microbe?

A

Obligate Intracellular Protazoan

25
Q

Effects of Toxoplasmosa gondii in a normal person?

A

Subclinical infection or mild lymphadenopathy

26
Q

Toxoplasmosa gondii is spread how (usually)?

A

Reproduces in cat intestinal epithelium
Shed in feces
Oocytes mature in 24 hours

27
Q

Toxoplasmosa gondii in mom’s first trimester leads to…

A

Severe disseminated infection
Fatality rate of 25%
Transplacental Transmission

28
Q

Toxoplasmosa gondii in mom’s third trimester leads to…

A

Chorioretinitis/Blindness

29
Q

Toxoplasmosa gondii in AIDS patients leads to….

A

Encephalitis

30
Q

Pathogenesis of Toxoplasmosa gondii in normal person?

A

Can infect all cell types by binding laminin receptors

Lymphoid Hyperplasia

31
Q

Pathogenesis of Toxoplasmosa gondii in IC and neonates?

A

Extensive destruction of the CNS, Liver, Heart, Lungs, Adrenals

32
Q

What can Toxoplasmosa gondii do in AIDS patients (other than swell the brain)

A

Reactivate a latent infection

33
Q

Leptospirosis symptoms in mild disease

A

Acute, self limited, febrile illness
Biphasic Fever and meningeal irritation
Conjunctival irritation and hyperemia

34
Q

How is Leptospirosis transmitted?

A

Excreted in dog urine

Also transmitted in water contaminated with animal products

35
Q

More severe Leptospirosis symptoms?

A

Lymphocytic atypical meningitis: severe Leptospirosis with jaundice, bleeding, and renal failure (Weil’s Disease)

36
Q

Pathogenesis of Leptospirosis?

A

Leptospirae disseminate through liver, spleen, kidneys, CNS with minimal cellular rxn
Lymphocytes appear in immune phase
Looks like viral meningitis

37
Q

How do people get Rabies?

A

Wild dogs cause to most cases worldwide

In US – mostly bats, some raccoons, foxes, skunks, and coyotes

38
Q

Rabies is histologically identified by…

A

Negrii bodies in nerve cells

39
Q

How is Rabies diagnosed?

A

Direct examination of brain tissue from an infected animal

40
Q

How is Rabies treated?

A

gamma globulin

41
Q

Three diseases primarily assocaited with Cats

A

Pasteruella multocida
Cat-Scratch (Bartonella)
Toxoplasmosis

42
Q

Two primarily dog related diseases?

A

Leptospirosis

Rabies

43
Q

Lymphocytic choriomeningitis virus is carried by

A

Hamsters and other pocket pets

44
Q

pathologic mechanism of anthrax?

A

Antiphagocytic activity, Edema Factor, Cytotoxic Factor
Infections associated with leukopenia
Can cause meningitis, electrolyte imbalane
Death by DIC

45
Q

How to treat anthrax?

A

Penicillin

Doxy

46
Q

Listeria monocytogenes method of transmission?

A
  • Contact with infected abortion, stillbirth, or neonatal sepsis from infected animals
  • Unpasteurized Milk and Milk Products
  • Contaminated Silage, forage
  • Vaginally during childbirth
47
Q

Forms of Listeria monocytogenes

A

Abortion (amnionitis)
Neonatal Sepsis
Meningitis (in IC adults)

48
Q

How is Brucellosis transmitted?

A

Contact with infected tissues
Unpasteurized milk and milk Products
Occupational exposure for vets/meat workers

49
Q

Forms of Brucellosis?

A
  1. Symmetrical bacterial disease with bacteremia, fever granulomatous inflammation of lymphoreticular system –> hepatosplenomegaly
  2. Rarely, pneumonias
50
Q

Pathologic mechanisms of Brucellosis?

A

Intracellular habitat and macrophage activation

51
Q

How is Q Fever transmitted?

A

By Tick

52
Q

Symptoms of Q Fever?

A

Headache, Cough, Myalgia, Lymphadenopathy, hepatosplenomegaly
2. Rare pneumonias

53
Q

Mechanism of Q Fever?

A

Nonspecific Necrosis
Mononuclear Infiltrates
Fibrin Exudates

54
Q

What are Glanders and Melioidosis caused by?

A

Pseudomonas mallei and pseudomallei

55
Q

Glanders and Melioidosis animal reservoirs?

A

Horses, Donkeys, Mules

56
Q

Glanders and Melioidosis symptoms

A 
Local papular abscess
Regional lymph nodes
Satellite, Pyemic Abscesses
Bacteremia
Fatal Lung Involvement

Pathology -- Infectious Disease (23 decks)

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