Infectious Disease -- Bacteria II bonus questions from the packet

Question 1

Strep pneumo, E Coli, N. meningitidis, H flu type B.

Which ones are exogenous?

Answer 1

N. meningitidis

H. flu

Question 2

Which is more deadly, Sepsis/DIC or meningits

Answer 2

Sepsis/DIC

Question 3

Which types are bacteria are prone to NOT cause DIC

Answer 3

G Positives are not interested in causing coagulation like crazy. Its the negative ones that want to see the world clot.

Question 4

Capsule type for S. pneumo, N. meningitidis, N. gonorrhea, H influenzae

Answer 4

Pneumo – Penumococcal Protein C
N. miningitidis – LPS
N. gonorrhea – LOS
H. flu – LPS

Question 5

Source of most cases of community-acquired, lobar pneumonia

Answer 5

Strep. pneumo

Question 6

Most common cause of death in influenza

Answer 6

S. pneumo

Question 7

Most important virulence factor in S. pneumo?

Answer 7

PspC
The protection it provides requires active complement components (C3) and the production of antibodies to be produced to allow phagocytosis

Question 8

Pathology seen in S. pneumo

Answer 8

Puruent lesions with creamy, white pus

In Pneumonia – alveoli filled with fluid+neutrophils

Question 9

Neisseria have complex nutritional requirements, such as…

Answer 9

Iron

Question 10

N. meningitidis petechial rash is especially prevalent on…

Answer 10

Earlobes and extremities

Question 11

N. meningitidis can cause hemorrage into the adrenal. What’s this called?

Answer 11

Waterhouse-Friderichsen syndrome

Question 12

Severe H. flu disease is most commonly seen in what age range

Answer 12

1-6

Much less common since vaccination

Question 13

Symptoms of H. flu (Type B) invasive disease

Answer 13

Meningitis
Pneumonia
Epiglottitis

Question 14

What does the 3 months - 3 years represent?

Answer 14

The period in which young children are unable to make good antibodies in response to type b capsular antigens

Question 15

Moraxella catarrhalis has an exotoxin similar to….

Answer 15

Neisseria

Question 16

DPT vaccine makes antibodies that bind onto

Answer 16

pertussis exotoxin

Question 17

Difference inPertussis concentrations of dTAP and Tdap

Answer 17

DTap – built for kids under 7, higher pertussis conc.

Tdap – intended for ages 10 and up

Question 18

Average age of a diptheria patient?

Answer 18

2-15 yo

Question 19

Cellular changes caused by diptheria exotoxin

Answer 19

Fatty myocardial changes, myofiber necrosis, and polyneuritis

Question 20

Three types of patients who should really watch out for pseudomonas

Answer 20

CF, Severe Burns, Neutropenia

Question 21

Pseudomonas “blue haze” is associated with…

Answer 21

Thrombosis and hemorrhage

Question 22

Pseudomonas forms biofilms with…

Answer 22

Protective exopolysaccharide

Question 23

Pseudomonas induces tissue injury with…

Answer 23

Phospholipases

Iron containing compounds toxic to endothel. cells

Question 24

Pseudomonas often co-infects with

Answer 24

Burkholderia cepacia complex

Question 25

Who is most likely to get Legionella

Answer 25

Individuals with pre-disposing lung/heart disease

Organ transplant recipients

Question 26

Purpose of H. pylori urease?

Answer 26

Creates protective layer of ammonia around the organism

Question 27

What part of the stomach is H. pylori commonly found in?

Answer 27

Antrum

Question 28

H. pylori causes ___% of duodenal ulcers

Nearly __% of affected adults are asymptomatic

Answer 28

90

50

Question 29

How does PsPA block alternative complement pathway?

Answer 29

Interferes with complement factor B

Question 30

Pneumolysin binds to

Answer 30

Fc region of IgG