Infections for Patho Flashcards
This flashcard deck was created using Flashcardlet's card creator
Microorganisms normally living in or on body
Microflora
Microorganisms are multiplying in or on a host
Infection or colonization
What cause disease?
Pathogens
Pathogen capable of producing infection when host is weakened
Oppurtunistic pathogen
Small modified infectious host proteins
Prions
Manner of replication of prions
Not clearly known or understood
Where do bacteria like to grow?
Warm moist places
What stage is active replication without recognizable symptoms in host?
Incubation
Stage with initial appearance of symptoms most commonly malaise
Prodromal
When are you most highly infectious?
Prodromal stage
What stage is the maximum impact of infectious process with rapid proliferation and dissemination of pathogen
Acute
Stage where there is containment if the infection, elimination of pathogen, repair of danger tissue, and resolution of symptoms
Convalescent
What stage is total elimination of pathogen and no S/S of disease?
Resolution
When are you not infectious anymore?
Resolution stage
-itis
Inflammation
-emia
In the blood
Bacterial toxins in the blood
Sepsis or septicemia
Make an infection more likely to cause disease
Virulence factor
Exotoxins
Outside
Endotoxins
Inside
Help infective organism stick to body
Adhesion factor
Help keep immune system from killing infective agent
Evasive factor
After exposure to an infectious agent the body produces antibodies
Serology
Antibody that rises during the acute phase then falls
IgM
Antibody that remains elevated after the acute phase
IgG
What is the genetic material of viruses?
DNA or RNA but not both
What do viruses need to replicate and why?
Host cell because they have no metabolic capability
What happens when a host cell is “transformed”?
It carries the virus
What is a virus responsive to that makes it become active?
Stress or hormonal changes
What are the effects of viruses?
Protein synthesis stops, enzymes kills cells, host cells fuse, secondary bacterial infections
Where is HSV type 1 located?
Above the belt
Where is HSV type 2 located?
Below the belt
Inflammation of the dorsal root ganglia
Shingles
What are the 3 ways antivirals work?
Interfere with nucleic acid synthesis, do not allow binding of cells to virus, and stimulate the body’s immune system
Used to treat HSV, HSV 2, and varicella zoster
Acyclovir
How is acyclovir most commonly administered?
Topical
Does acyclovir cure the illnesses?
No it decreases the length of them
What is a risk of giving acyclovir with AZT?
Neurotoxicity
Used for treatment of HIV
Zidovudine
How does zidovudine work?
Inhibits reverse transcriptase for replication
What is an important SE of zidovudine?
Bone marrow suppression
Drugs that reduce the duration of influenza A and B
Tamiflu and Relenza
When should you start Tamiflu and Relenza?
Within 2 days of first symptoms
When should you not give antivirals?
If patient has herpes zoster or is immunosuppressed
One celled organisms with no true nucleus
Bacteria
Released when the bacterial cell wall decomposes
Endotoxins
Released during cell growth
Exotoxins
Why are endotoxins pyrogenic?
Due to lysis of bacteria
Bacteria requires oxygen
Aerobic
Bacteria doesn’t require oxygen
Anaerobic
Bacteria in blood
Septicemia
How is TB transmitted?
Droplet
What is the usual protocol for TB treatments?
Drug susceptibility tests, start 4-drug regimen, adjust after susceptibility test results
What is a must in TB treatments?
Patient compliance
How long is TB treatment?
6 months
What TB drug inhibits protein synthesis?
Rifampin
What TB drug inhibits cell wall synthesis?
Isoniazid
When giving isoniazid what is it important to monitor?
Liver
What is a SE of rifampin?
Bodily secretions turn red-orange/brown
When do you take TB meds?
With meals
Infection caused by fungus
Mycosis
Mycotic infection that affects lungs
Blastomycosis
What are examples of mycotic cutaneous infections?
Candidias, dermatophytes, and tinea
Med for systemic mycoses
Amphotericin B
What can amphotericin B do to potassium levels?
Decrease them
What drug do you use caution with when giving amphotericin B?
Digoxin
What is a bad side effect of amphotericin B?
Nephrotoxic
What other drug can you give besides amphotericin B and why would you?
Fluconazole because it has less SE
What can fluconazole increase?
Anticoagulant effects and phenytoin levels
How do fungi reproduce?
Division
What are the two classifications of fungi?
Yeasts and molds
Single celled or multi celled organisms
Parasites