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Life Cycle > II: Placental Pathology and Trisomies > Flashcards

II: Placental Pathology and Trisomies Flashcards

1
Q

________ DNA is required for development of embryonic tissue

A

Maternal

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2
Q

________ DNA is required for development of placental tissue

A

Paternal

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3
Q

How is an intervillous thrombus diagnosed?

A

Kleihauer-Betke Test: HbF assay (>20% of fetoplacental circulation abnormal)

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4
Q

How many sperm are typically involved in growth of a complete mole?

A

One

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5
Q

p57kip2 is _____ expressed and _______ imprinted

A

Maternally; Paternally

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6
Q

What is the nomenclature for pregnancies?

A

TPAL (Term, Premature, Aborted, Living)

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7
Q

What management is indicated for a complete mole?

A

hCG level monitoring

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8
Q

What type of staining can be used to demonstrate the type of mole?

A

p57kip2

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9
Q

Which genetic anomaly? Abnormal fluid collection under skin, within abdomen, or within chest cavity

A

Fetal Hydrops

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10
Q

Which genetic anomaly? Low AFP and estriol; high beta-hCG and inhibin

A

Trisomy 21

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11
Q

Which genetic anomaly? Low AFT, estriol, beta-hCG; normal inhibin

A

Trisomy 18 (Edwards Syndrome)

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12
Q

Which genetic anomaly? Micrognathia, Rocker-bottom feet, heart anomalies, renal fusion, omphalocele

A

Trisomy 18 (Edwards Syndrome)

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13
Q

Which genetic anomaly? Polyhydramnios, fetal tachycardia, decreased fetal movement

A

Fetal Hydrops

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14
Q

Which genetic anomaly? SGA, Round/flat flace with slanting palpebral fissures, duodenal atresia, ASD

A

Trisomy 21

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15
Q

Which genetic anomaly? Short stature, webbing, cystic hygroma, gonadal hypoplasia, cardiac anomalies

A

Turner Syndrome

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16
Q

Which genetic anomaly? Small for gestational age, polydactyly, facial defects, cutis aplasia, VSD, normal quad screen

A

Trisomy 13 (Patau Syndrome)

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17
Q

Which pathology? Associated with fetal stress or maturity; can result in aspiration pneumonia or myonecrosis; associated with post-dates, low Apgars, neuro-developmental delay

A

Meconium

18
Q

Which pathology? Atherosis with foamy macrophages, widely spaced villi, large syncytial knots

A

Pre-eclampsia

19
Q

Which pathology? Detachment of placenta from decidual seat

A

Placental Abruption

20
Q

Which pathology? Failure of decidual formation, trophoblast invasion into myometrium

A

Placenta Accreta

21
Q

Which pathology? Feto-maternal hemorrhage, laminated appearance with lines of Zahn

A

Intervillous Thrombus

22
Q

Which pathology? Fibrin clot with rim of villous infarction, possible evidence of bleeding during pregnancy

A

Placental Abruption (Chronic)

23
Q

Which pathology? Group B strep infection of fetal membranes

A

Acute Chorioamnionitis

24
Q

Which pathology? Hemorrhagic, well-circumscribed nodule in uterus; proliferation of trophoblast and syncytiotrophoblasts in a biphasic pattern

A

Choriocarcinoma

25
Q

Which pathology? Intranuclear basophilic inclusions surrounded by a halo, often asymptomatic, may cause IUFD, IUGR, deafness

A

CMV placentitis

26
Q

Which pathology? Intravillous bleeding with bags of blood appearance

A

Placental Abruption (Acute)

27
Q

Which pathology? Lack of myometrial contractions after delivery

A

Post-Partum Hemorrhage

28
Q

Which pathology? Most common neoplasm of newborn

A

Sacrococcygeal Teratoma

29
Q

Which pathology? Neutrophils in fetal membranes, fever, leukocytosis, tachycardia, uterine tenderness

A

Acute Chorioamnionitis

30
Q

Which pathology? Placental invasion through uterine wall

A

Placenta Percreta

31
Q

Which pathology? Thin walled vessels with endothelium replaced by trophoblast, deposition of dense pink fibrinoid around vessels

A

Pre-eclampsia

32
Q

Which pathology? Vaginal bleeding, abdominal/back pain, rapid uterine contractions; risk factors: trauma, cocaine, clotting disorders

A

Placental Abruption

33
Q

Which type of mole? “grape-like vesicles” and “snowstorm” appearance

A

Complete

34
Q

Which type of mole? 20% may develop into persistent Gestational Trophoblastic Disease

A

Complete

35
Q

Which type of mole? Diandric

A

Both

36
Q

Which type of mole? Diploid

A

Complete

37
Q

Which type of mole? Do not recur or regress

A

Partial

38
Q

Which type of mole? Hydropic villi, circumferential trophoblast proliferation, central cisterns

A

Complete

39
Q

Which type of mole? Large cystic spaces with possible fetal tissue

A

Partial

40
Q

Which type of mole? P57kip2 mutation

A

Complete

41
Q

Which type of mole? Triploid

A

Partial

Life Cycle (24 decks)

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