I: Male Reproductive Disorders Flashcards
___ cells: create a barrier between the interstitial and seminiferous fluid
Sertoli
_____ stimulates GnRH secretion.
IGF-1
Androgens and estrogens inhibit _____ release at the ______.
LH, FSH; pituitary
Androgens inhibit _____ release at the _____.
GnRH; hypothalamus
hCG recapitulates the action of __, which human menopausal gonadotropin has a similar action to ___.
LH; FSH
In acquired causes of hypergonadotropic hypogonadism, does LH or FSH tend to rise first?
FSH (due to loss of inhibin)
In Klinefelter’s syndrome, ____ cells are intact and ____ cells are absent.
Leydig, Sertoli
Name 4 adverse effects of androgens at supraphysiologic doses.
Polycythemia, BPH, increased LDL, increased cardiac events
Name 5 acquired causes of hypergonadotropic hypogonadism.
Alcohol, Testicular torsion, mumps orchitis, diabetes, chemotherapy/radiation
Name 8 causes of hypogonadotropic hypogonadism.
Functional, stress, OSA, pit tumor, lymphocytic hypophysitis, hemochromatosis, hypothyroidism, Cushing’s syndrome
Name two pharmacologic treatments for erectile dysfunction.
PDE inhibitors, Prostaglandin E injections
What is the treatment for primary hypothalmic defects?
Pulsatile GnRH
Which cause of hypogonadism is worsened by treatment with testosterone?
OSA
Which cause of hypogonadism? High FSH, normal LH initially with declining levels, low-normal T
Klinefelter Syndrome
Which central cause of hypogonadism involves high LH/FSH and low T?
Pituitary Glycoprotein tumor
