I: Male Pathology Flashcards
______ prostate zone: inverted cone with base at the base of the prostate and apex at the verumonatorum
Central
______ prostate zone: Surrounding zone posteriorly, laterally, and apically
Peripheral
______ prostate zone: two lobes surrounding prostatic urethra laterally and anteriorly
Transition
_______: squamous cell CIS involving genital skin
Bowen’s Disease
_______: squamous cell CIS involving mucosal surface of uncircumcized glans penis
Erythroplasia of Queyrat
______: site of prostatic urethra merging with ejaculatory ducts, at which the urethra makes a 35-degree bend
Verumonatorum
Best marker for detection, staging, and monitoring of patients with prostate cancer
PSA
BPH most commonly occurs in the _____ zone.
Transition
Most common cause of infectious epididymitis/orchitis in children
Gram negative rods
Most common cause of infectious epididymitis/orchitis in sexually active adults
Neisseria, Chlamydia
Most common cause of infectious epididymitis/orchitis in the elderly
Enterobacteria
Prostate cancer is assigned a _____ grade based on similarity of glandular architecture to normal
Gleason
Prostatic adenocarcinoma most commonly occurs in the ____ zone.
Peripheral
Varicocele more oftenly affects the ___ testis.
left
Which pathology? Aberrant phagocytic process with bacterial fragments calcifying within phagocytes
Malakoplakia
Which pathology? Arrest in germ cell development, thickening of basement membrane, Leydig cell hyperplasia, hyaline replacement
Cryptorchidism
Which pathology? Caseating granulomas part of systemic disease
Tuberculous Orchitis
Which pathology? Difficulty starting/stopping urination, increased urinary frequency, nocturia
BPH/adenocarcinoma
Which pathology? Diffuse mononuclear interstitial infiltrate rich in plasma cells, obliterative endarteritis, +/- gummas
Syphilis
Which pathology? Dilation and tortuosity of veins in pampiniform plexus
Varicocele
Which pathology? GCT in older men, cells resemble primary and secondary spermatocytes
Spermatocytic seminoma
Which pathology? GCT that may cause gynecomastia and precocious puberty, granular eosinophilic cytoplasm with intracytoplasmic crystals
Leydig Cell Tumor
Which pathology? GCT that secretes alpha-fetoprotein
Yolk Sac Tumor
Which pathology? GCT with fish-flesh appearance
Seminoma
Which pathology? GCT with frequent metastases, secretes beta-hCG
Choriocarcinoma
Which pathology? GCT with heterogenous elements; good prognosis in children/variable in adults
Teratoma
Which pathology? Inspissation of secretions to form sand-like substance in prostate
corpora amylacea
Which pathology? Lymphocytic and plasma cell infiltration of prostate parenchyma
Chronic prostatitis
Which pathology? Mononuclear inflammatory infiltrate with interstitial edema, infertility uncommon, usually subsequent to parotid involvement
Mumps orchitis
Which pathology? More aggressive than seminomas, small tumors; large hyperchromatic pleomorphic nuclei and indistinct cytoplasm with frequent mitoses
Embryonal carcinoma
Which pathology? Most common cancer in males
Prostatic Adenocarcinoma
Which pathology? Most common penile cancer
Squamous Cell Carcinoma
Which pathology? Most common testicular tumor in infants/children, loose/maze-like network of cells
Yolk Sac Tumor
Which pathology? Most common testicular tumor in men over age 60
Lymphoma
Which pathology? Most common type of germ cell tumor
Seminoma
Which pathology? Neoplastic condition arising from condylomatous lesion with local invasion
Verrucous carcinoma
Which pathology? Neutrophilic inflammation of prostate due to S. aureus, E. coli, or enterobacteria most commonly
Acute prostatitis
Which pathology? Nodular aggregation of histiocytes containing calcified intracytoplasmic inclusions (_____ bodies)
Malakoplakia; Michaelis-Gutmann
Which pathology? Occur in young men (15-35) with painless testicular enlargement
Germ Cell Tumor
Which pathology? Placental differentiation with cytotrophoblasts and syncytiotrophoblasts
Choriocarcinoma
Which pathology? Tubular sclerosis, Leydig cell hyperplasia, infertility
Klinefelter Syndrome
Which pathology? Tuffed, papillary, or cribriform proliferation of atypical cells surrounded by basal cell layer (Prostate)
Prostatic Intraepithelial Neoplasia
Which pathology? Undescended testes located anywhere along the path of descent
Cryptorchidism
Which pathology? Uniform population of large polygonal cells with distinct cell membrane, clear cytoplasm, central nucleus; may have hCG-producing giant cells
Seminoma
Which pathology? Variable glandular and stromal hyperplasia with dilatation of glands and papillary infoldings (Prostate)
BPH
Which pathology? Yellowish or inapparent nodule, proliferation of cuboidal or columnar cells in a single-layered epithelium (prostate)
Adenocarcinoma
Which typically occurs first: epididymitis or orchitis?
Epididymitis
