I: Estrogen/Progestin Pharmacology

Question 1

Estrogen _____ LDL, _____ HDL, and _____ TGs.

Answer 1

Decreases; Increases; Increases

Question 2

Menopausal hormonal treatment is used to treat which symtpoms?

Answer 2

Urogenital, Vasomotor, Vaginal Dryness

Question 3

Progestin _____ aldosterone secretion and ______ sodium reabsorption

Answer 3

increases; decreases

Question 4

Progestin _____ hepatic glycogen deposition.

Answer 4

increases

Question 5

Progestins stimulate ______ to promote fat deposition.

Answer 5

Lipoprotein Lipase

Question 6

What are options for vasomotor symptom treatment in women that cannot use hormonal replacement therapy?

Answer 6

SSRIs, SNRIs, Clonidine, Gabapentin

Question 7

Which agent? Postcoital contraceptive that alters oviduct motility and causes endometrial changes

Answer 7

Plan B (levonorgestrel)

Question 8

Which agent? Postcoital contraceptive that modulates the progesterone receptor to delay follicular rupture

Answer 8

Ulipristal/Ella

Question 9

Which agent(s)? 1st generation progestin

Answer 9

Norethindrone

Question 10

Which agent(s)? 2nd generation progestin

Answer 10

Levonorgestrel, Norgestrel

Question 11

Which agent(s)? 3rd generation progestin

Answer 11

Desogestrel, Norgestimate

Question 12

Which agent(s)? 4th generation progestin

Answer 12

Drospirenone

Question 13

Which progestin agents may have less androgenic activity?

Answer 13

3rd-generation (Desogestrel, Norgestimate)

Question 14

Which SERMs? Decreases osteoclast activity

Answer 14

Tamoxifen, Raloxifene

Question 15

Which SERMs? Improves vasomotor symptoms

Answer 15

None

Question 16

Which SERMs? Increases endometrial growth

Answer 16

Tamoxifen

Question 17

Which SERMs? Increases hepatic metabolic effects

Answer 17

Tamoxifen, Raloxifene

Question 18

Which SERMs? Inhibit breast growth

Answer 18

Tamoxifen, Raloxifene