I: Puberty Flashcards
FSH/LH levels: Prepubertal: ___>___
FSH; LH
FSH/LH levels: Pubertal: ___>___
LH; FSH
______: caused by gonadal dysgenesis, galactosemia, radiation, chemotherapy, or autoimmune causes
Primary Ovarian Failure
______: hyalinization and fibrosis of seminiferous tubules, microphallus, small testes, learning disabilities, infertility, gynecomastia
Klinefelter Syndrome
______: idiopathic hypogonadotropic hypogonadism and anosmia/hyposmia
Kallman syndrome
______: primary ovarian failure with dysmorphic facies, hx of otitis, CV defects, thyroiditis
Turner Syndrome
_____: activating mutation in GPCR of LH receptor
McCune Albright Syndrome
_____: early development of pubic/axillary hair, body odor, acne
Early adrenarche
_____: Most common cause of hypogonadotropic hypogonadism
Constitutional Growth Delay
_____: mutation in LH receptor, causing it to be constitutively activated
Familial Testotoxocosis
_____: precocious puberty, café au lait spots, polyostotic fibrous dysplasia
McCune Albright Syndrome
_____: premature breast development without growth acceleration, bone age advancement, or other pubertal changes
Early thelarche
_____: testes enlarged but not to the extent expected by virilization
Familial Testotoxocosis
Increase in LH in a GnRH stimulation test suggests ______ precocious puberty
Central
Name 3 signs of adrenarche.
Hair growth, body odor, acne
Name the early and mean age of girls beginning puberty (Tanner 2 breast development).
8, 10.4 (Caucasian); 6.6, 9.5 (Black)
Name the early and mean age of menarche.
10.6, 12.5 (Caucasian); 9.7, 12 (Black)
Name the mean ages at which boys attain 3ml testes, acquire pubic hair, show penile enlargement, and reach peak growth velocity
11.8, 12, 13, 14
Name two genetic causes of hypogonadotropic hypogonadism.
Septo-optic dysplasia, Prader-Willi Syndrome
Treatment for Constitutional Growth Delay
Consider short course of testosterone or estrogen treatment
Treatment for primary gonadal failure
Testosterone or estrogen followed by estrogen/progesterone cyclic therapy
Treatment of central precocious puberty
GnRH analogue
Treatment of Familial Testotoxicosis
Aromatase Inhibitor + Androgen blocker
Treatment of McCune Albright Syndrome
Aromatase Inhibitor
Which age defines delayed puberty?
Girls: 13, Boys: 14
