I: Androgen Pharmacology

Question 1

Name first and second line agents used in treatment of BPH.

Answer 1

alpha-1-inhibitors, 5-alpha-reductase inhibitors

Question 2

Name four drugs classes used in prostate cancer treatment.

Answer 2

GnRH agonist, GnRH antagonist, androgen receptor blocker, 5-alpha-reductase inhibitor

Question 3

Name the drug and its mechanism for the treatment of alopecia.

Answer 3

Finasteride, 5-alpha-reductase inhibitor

Question 4

Name the drug: 5-alpha-reductase inhibitor

Answer 4

finasteride, dutasteride

Question 5

Name the drug: androgen receptor blocker

Answer 5

bicalutamide, gynecomastia

Question 6

Name the drug: GnRH agonist.

Answer 6

Leuprolide

Question 7

Name the firstline treatment for precocious puberty.

Answer 7

Continuous GnRH agonist

Question 8

Which anti-androgen drug class is notable for causing decreased libido and erectile dysfunction?

Answer 8

5-alpha-reductase inhibitors

Question 9

Which anti-androgen drug class may cause headaches, nausea, and hypogonadism with prolonged treatment?

Answer 9

GnRH agonists

Question 10

Which testosterone administration? Administration bid/tid with reduced likelihood of transfer to child

Answer 10

Buccal, Nasal

Question 11

Which testosterone administration? Administration every 1-3 weeks

Answer 11

IM

Question 12

Which testosterone administration? Can cause severe skin rash necessitating discontinuation in 1/3 of patients

Answer 12

Transdermal Patch

Question 13

Which testosterone administration? Given every 3-6 months, cannot adjust dose

Answer 13

SC pellets

Question 14

Which testosterone administration? Less oftenly used due to hepatic side effects

Answer 14

Oral

Question 15

Which testosterone administration? Most expensive, most stable testosterone levels throughout dosing period

Answer 15

Transdermal Gel