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Life Cycle > II: Parturition and Pharmacology > Flashcards

II: Parturition and Pharmacology Flashcards

1
Q

_____ stimulation leads to relaxation of the myometrium around the time of delivery

A

Beta-adrenergic

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2
Q

______ stimulate uterine contractions

A

Prostaglandins, oxytocin

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3
Q

_______ induce labor

A

Prostaglandins

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4
Q

CRH ____ cortisol levels, which feeds back to ______ CRH production by the placenta

A

increase; increase

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5
Q

List 4 contraction-activated proteins.

A

Calcium channels, Oxytocin receptors, Prostaglandin receptors, gap junctions

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6
Q

List the phases of myometrial contraction (0-3).

A

Quiescence; Activation; Stimulation; Involution

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7
Q

PDE5Is should not be administered with which drugs?

A

Alpha blockers, nitrates

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8
Q

Post-partum bleeding is controlled hormonally by ______

A

Oxytocin

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9
Q

Prostglandins promote release of _______ that helps lead to facilitate membrane rupture

A

Metalloproteinases

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10
Q

Surfactant proteins increase ______ activity in the amnion

A

COX-2

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11
Q

Which clinical stage of labor? Complete dilation to delivery of fetus

A

2

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12
Q

Which clinical stage of labor? Delivery of the fetus to delivery of the placenta

A

3

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13
Q

Which clinical stage of labor? Effective contraction to complete dilatation of the cervix

A

1

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14
Q

Which clinical stage of labor? First 6 hours after delivery

A

4

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15
Q

Which drug? Administered with mifepristone

A

Misoprostol

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16
Q

Which drug? First line agent for post-partum hemorrhage

A

Oxytocin

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17
Q

Which drug? Folic acid antagonist, disrupts rapidly growing tissues

A

Methotrexate

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18
Q

Which drug? Limited use close to labor due to risk of closing ductus arteriosus

A

Indomethacin (NSAID)

19
Q

Which drug? May inhibit pituitary oxytocin, not effective in delaying labor

A

Alcohol

20
Q

Which drug? Oral abortifacent

A

Mifepristone

21
Q

Which drug? Progesterone competitive receptor antagonist

A

Mifepristone

22
Q

Which drug? Progesterone metabolite administered weekly for mothers at high risk of preterm delivery

A

17-alpha-hydroxyprogesterone caproate

23
Q

Which drug? Prostaglandin analog as vaginal gel or oral administration

A

Dinoprostone; Misoprostol

24
Q

Which drug? Prostaglandin analog with uterine contractility properties; may cause abdominal cramps and n/v

A

Misoprostol

25
Q

Which drug? Relaxes uterine smooth muscle with fewer side effects than other agents

A

CCBs (nifedipine)

26
Q

Which drug? Suppresses contraction and preterm labor, less effective if cervix is already dilated; may cause tachycardia, hypokalemia, hyperglycemia, pulmonary edema

A

Beta-2-agonist/Terbutaline

27
Q

Which drug? Used for eclampsia; blocks calcium action; may rarely cause pulmonary edema, hypotension or muscle paralysis

A

Magnesium Sulfate

28
Q

Which drug? Used for induction after cervical ripening

A

Oxytocin

29
Q

Which drug? Used for post-partum hemorrhage refractory to treatment with oxytocin

A

Ergot alkaloids (ergonovine, methylergonovine)

30
Q

Which hormone? Activate potassium channels to increase threshold required for depolarization

A

Beta-Sympathomimetic

31
Q

Which hormone? Activates myosin light chain kinase and activates prostaglandins

A

Oxytocin

32
Q

Which hormone? Activates Protein Kinase C pathway to increase intracellular calcium

A

CRH

33
Q

Which hormone? Acts in a paracrine fashion increase intracellular calcium levels by activation of ligand-gated channels

A

Prostaglandins

34
Q

Which hormone? Blocks myosin light chain kinase and inactivates prostaglandins

A

Progesterone

35
Q

Which hormone? Facilitates weakening of chorion and amnion

A

Prostaglandins

36
Q

Which hormone? Functions for quiescence earlier in pregnancy and contraction late in pregnancy

A

CRH

37
Q

Which hormone? High levels are associated with preterm labor

A

CRH

38
Q

Which hormone? Increased activation of contractility generated by change in receptor isotypes

A

CRH

39
Q

Which hormone? Number of receptors greatly increases at time of parturition

A

Oxytocin

40
Q

Which hormone? Stimulates contractions, greatest action at fundus

A

Oxytocin

41
Q

Which PDE5I? Back and muscle pain

A

Tadalafil

42
Q

Which PDE5I? Decrease blood pressure

A

Sildenafil, vardenafil

43
Q

Which PDE5I? Longest half-life

A

Tadalafil

44
Q

Which PDE5I? Loss of blue-green color discrimination, blurred vision

A

Sildenafil

Life Cycle (24 decks)

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