IDR block 4b Flashcards
EBNA-1,2,3 causes what? These genes are considered latent/lytic or both?
Oncogenic cells and lymphomas Both latent and lytic
Ebstein Barr Virus
If there is splenic rupture, Guillan Barre Syndrome, or meningoencephalitis, what herpes sequeale are we working with most likely in an immuncompromised patient?
Kissing disease, infectious Mononucleosis, EBV
What is a big tip off that infectious mononucleosis has been contracted?
Exudative Pharyngotonsilitis
What herpes sequela is seen below? What must most patients have or be in order to have this disease?
Oral Hairy Leukoplakia Immuncompromised
Burkitts Lymphoma, is usually caused by what? Will normally have what with it?
Herpes Sequeale, more TH2 response versus TH1, Eukaryotic parasites
What translocation is important for Burkitts Lymphoma? What gene is constantly turned on due to gene problem?
8 to 14 C-myc
EBV Lymphoproliferative Disease is caused by a lack of what in the human body?
IFN gamma, TNF alpha, T cell depleted Bone marrow
EBV makes too many what? What is picture indicative thereof?
Antibodies
EBV
What does the Recognition of Paul-Bunnell antigen indicate on agars?
What is the first thing that is attacked on the EBV antigens?
Is there a good treatment?
The presence of heterophile antibodies, production of heterophile antibodies
VCA-IgM
No good treatment
Kaposi’s sarcoma-associated herpes virus (KSHV) is what type of herpes?
What is the numerical notation of KSHV?
Gamma Herpes Virus
HHV-8
What does Kaposi’s Sarcoma-associated herpes virus rash look like?
What population will this show up the most in?
Barton Hesalea
Immuncompromised patients
Beta Herpesvirus encompasses what viruses?
Of the the viruses, which one can cross the placenta?
What is the respective number?
CMV
HHV-5, CMV
HHV-6, HH-7 (Roselia, big rash, fever, and self resolves)
How is CMV moved from patient to patient? Provided it can be held latent in T-Cells and Macrophages
Repression of what immune system piece causes CMV to proliferate?
Blood and tissue secretion
Cell mediated Immunity
CMV and EBV present with very similar symptoms, what is a good way to tell them apart?
CMV will not have the crazy proliferation of B cells
The baby is born as seen in the picture? What disease does the baby have, assuming a viral infection, and what other symptoms can be expected?
Congenital CMV
Microcephaly, Underweight, and Mental Retardation
What is evidence of a post natal baby infection, Congenital CMV infection?
What does CMV look like on a histology slide?
What other test can be used?
Mononucleosis features, Pneumonia, Hepatitis, and Deafness
Owls eyes, large inclusion bodies
PCR
What does Ganciclovir do differently than ACV?
Which is more toxic?
Ganciclovir is activated via a different protein kinase
Ganciclovir is more toxic
What do Ganciclovir, Valganciclovir, and Cidofovir all do?
What does Foscarnet do?
Prodrugs that are converted via a protein kinase, nucleotide analog
Foscarnet, is an altered phosphate group
What symptoms would an immuncompromised patient have with a CMV virus?
Penumonia, meningitis, Exophagitis, Colitis, and Hepatitis
What is another way to double check for the mono virus? (via a lab test)
Heterophile-positive mononucleosis syndrome
What kind of glycoproteins are made for HBV?
HBsAG is what?
S, M, L glycoproteins
Surface protein for Hepatitis
What is the polymerase P and X (proteins, used for)?
Polymerase P is the traditional reading frame, takes mRNA into HBsAg, HBeAg, and HBcAg not mention Reverse Transcriptase activites that replicate Hep B DNA viruses
Polymerase X does transcription and pushes pieces of DNA into human genome
Subviral lipoproteins do not contain any what?
Nucleic Acid
What is the number one viral cause of congenital defects?
Can cause Seizures, Deafness, Jaundice
CMV
MCV shows up what way through what bodies?
Where wont you see lesions? Non gential lesions
Henderson Paterson
palms and soles
What pox virus starts on the hand?
Cowpox
Cidofovir kills all what?
What virus can be killed via a cream?
viral infected cells
MCV
Lamivudine treats HIV and HBV, what can it attack that they both have?
What kind of HBV vaccine is given?
Reverse Transcriptase
Subunit
What is given in the subunit HBV vaccine?
What can be given with an HBV vaccine?
HBsAg
Give antibodies to prevent movement into cells
When it comes to the EBV LMP-1, LMP-2, and EBER are responsible for causing what?
EBV-EA, EBV-MA, EBV-VCA are lytic stage genes that are responsible for what?
Latent infection cells
Early, membrane, and viral capsid antigens
Kaposi sydrome has what unique characteristic? Has what distinct color?
Angiogenic and purple color
How is VZV transferred from person to person?
Respiratory and Direct Contact
What genome types for HBV get into the human genome the easiest and therefore are more likely to cause cancer?
Can HBV cross the placenta?
Genomes B,C,E
No, cannot cross the placenta
What is the necessity of the RNA genome involving the RNA polymerase II? (with respect to Hep D)
Hep D can be diagnosed via what unique lab technique?
Allows Hep D to replicate
ELISA
What is the #1 and #2 most common viral infectious agents in humans?
1 Rhinovirus
What picornavirus receptor, an Ig-like receptor, will use what receptor?
CD155
How do I differentiate Hep A from Hep B.?
Hep. B the symptoms will show up afer 6 weeks, Hep. B is chronic in most kids
Hep. A the symptoms will show up after 2-4 weeks, Hep A is asymptommatic in kids
- Detection of anti-HAV IgM indicates ______ infection
- Detection of anti-HAV IgG indicates _______infection
What is the liver enzyme that is elevated in Hep A?
acute
previous
ALT
Hep B is what kind of vaccine?
Hep A is what kind of vaccine?
Subunit
Whole killed
Hep. A has similar seafood, fecal oral problem as what other bacteria?
Vibro Parahemolyticus
Who is Hep. E worse in? What standard lab tests can be used?
Preganant Women
No lab tests
What virus subgroup replicates in untreated water, outbreaks occurs in schools and daycares?
Enterovirus
Where does the enteroviruses replicate?
Replicates in the oropharynx, GI tract, and bloodstream
What two types of polio will a person have before they get paralytic poliomyelitis?
What is the worst type of polio?
Abortive poliomyelitis: flu like symptoms and headache
Non-paralytic poliomyelitis: aseptic meningitis
Bulbospinal Polio, can still have recurrent symptoms and shed virus in the stool
How is Cocksackie separated from Herpes?
S. Pyogenous has petechial rashes verus what with cocksackie?
Herpes is the same location, recurrent history, no fever
Cocksackie has vesicular lesion
Coxsackie B effects via pericarditis and myocarditis. What is the name of the disease?
What does CVB4 cause?
Pleurodynia (aka Bornholm disease, epidemic myalgia, “devil’s grip”)
Type 1 Diabetes, destroys the Islet of Langerhands, no more insulin
What number is the Coxsackie A virus for Hand-foot-mouth disease?
What number is the Coxsackie A Rhinovirus-like, cold-like syptoms?
CVA16
CVA21 and CVA24
What is the Coxsackie virus A number for conjunctivitis?
variant CVA24
What virus causes aseptic meningitis but is very unlikely?
What are the respective strains for Upper Respiratory Tract Infection?
Echovirus
EV11 and EV20
What number of echovirus causes pleurodynia like symptoms?
What number of echovirus causes hemorrhagic conjuctivitis?
EV6 and EV19
E70
How is Rhinovirus spread?
What temperature does Rhinovirus replicate?
Direct Person to Person via respiratory droplets
Contact via a fomite
Main cause of the common cold
33 Degrees, not 37 degrees, are acid labile
Large giant multinucleated cells?
Which virus
Tzank Smear
Herpes
Pox family has what histological tipoff?
MCV is what family, and has what histological tipoff?
What does MCV that is unique?
Guarnelli Bodies, large basophillic bodies
Henderson patterson Bodies
Ulcer, has cheese like center, painless, no palms or soles
A baby with diaherra and meningitis is what? viral infection
What uses ICAM-1 for binding?
Echovirus
Rhinovirus
