Block5b Flashcards
If there is a B cell deficiency, what type of bacteria will not be kept in check?
Pyogenic
If there is a T cell deficiency, what type of virus predominates?
EBV and Pneumocystis Jiroveci
When SCID occurs, what signaling subunit is missing?
Gamma (c)
What deficiency is a decrease in all B cell numbers?
How long does this take manifest itself?
What APC/Tcell interaction sites are underdeveloped?
X-linked agammaglobulinemia, lack of Bruton Tyrosine Kinase
6 months, mom’s antibodies run out
Germinal Centers
What is a deficiency of the IgG subclasses, sometimes associated with absent IgA or IgE?
Ig heavy chain deficiencies
What is the disease when there are decreased T cells, normal B cells (lower Ig)?
What is most likely missing?
DiGeorge Syndrome
Thymus
When there is Hyper IgM syndrome what part of a certain B-T Tango does not happen?
What is defective in the patient?
Class switching, stuck with IgM
CD40 ligand mutation
What is the most common variable immunodeficiency symptoms?
low levels of serum IgG, IgA, and IgM
What does a mutation for Wiskott-Aldrich sydrome cause?
Eczema, reduced platelets, and immunodeficiency
Reduced platelets is the worst one
What disease has a mutation in the ATM gene, does not allow for VDJ recombination, causes gait abnormalities, and low lymphocyte numbers?
Ataxia-telangiectasia
What do steroids turn off in the inflammation process?
Phospholipase
Schistosoma mansoni and japonicum lay there eggs where in the human body?
Liver and Gut
Schistosoma hematobium lays there eggs where in the human body?
bladder
Silver Stain and Calcoflour White has fungi appear on the media, what bacteria can show up on this media?
Legionella
Giemsa stain is used for detection of parasites, what bacteria show up on the stain as well?
Anaplasma, Ehrlichia, Borrelia Bordorfei
