Hypersensitivity Disease

Question 1

Autoimmune hemolytic anemia

Answer 1

Type II

Antibody directed against Rh blood group

Question 2

Autoimmune thrombocytopenia purpura

Answer 2

Type II

Antibody directed against platelets integrin or glycoprotein

Question 3

Goodpasture Sydrome

Answer 3

Type II

Antibodies against type IV collagen results in basement membrane disruption, leads to kidney damage and pulmonary hemorrhage

Question 4

Pernicious Anemia

Answer 4

Type II

Against membrane bound intestinal protein that uptakes B12

Question 5

Systemic Lupus Erythematosus

Answer 5

Type III

Middle aged women, fever weakness skin rash, kidney problems

Auto-Abs to DNA, histones, platelets, leukocytes, clotting factor

Antigen involved dsDNA

Excessive complement activation (will show as low amount of complements)

Screen with immunofluorescence

Question 6

Hashimoto Thyroiditis

Answer 6

Type IV

Middle aged women, targets thyroid antigens

Hypothyroidism

Question 7

Insulin Dependent Diabetes Mellitus

Answer 7

Type IV

Abs against beta cells that produce insulin

Question 8

Multiple Sclerosis

Answer 8

Type IV

Inflammatory lesions caused by T cells destroys myelin sheath

Question 9

Rheumatoid Arthritis

Answer 9

Type IV

Chronic inflammation of the joints

Auto-Abs that bind to Fc portion of IgG