41. Cell Mediated Immunity II Flashcards
A student is writing a paper on the fascinating world of Memory T lymphocytes. Which fact should he omit from his paper because it isn’t true?
A. Last Month to years B. Requires Il-17 C. Is Quiescent D. Responsible for secondary response E. Found in peripheral tissue
RFA
ANS. B Memory T lmphocytes require IL-7 not IL-17
IL-17 is important for recruiting neutrophils
28 year old women visit her dermatologist due to a fungal growth on her feet. Which signal is associated with this kinda of infection?
A. IL-1 B. IL-4 C. IL-10 D. IFNg E. IL-25
RFA
ANS A IL-1 is associated with fungal infections and extracellular bacteria
IL1, IL6 Il23 and TGF-B from NK cells stim . Tcells activating TH17 cells releasing IL-17, 21, 22
large inflammatory response
B, C D are all associated with Cell mediated response
Dendritic cells IL-12 NK cells INF-g activate T cells TH1 cells release INF-g (increase macrophages) IL-12(increase T1H) IL2(increase T1H) TNFa(inflammation)
E. is from the Humeral mediated response
IL-4 from mast and eosinophils stim TH2 releasing IL-4( increase mast and basophils) IL-5( increase eosinophils) IL10(stops Th1) IL25 (upregulates all the other release interleukins)
Which of the following is caused by a Th17 defect?
A. Chronic mucocutaneous candidiasis B. Tuberculoid Leprosy C. Eczema D. Shingles E. Lupus
SZ
Ans. A Chronic mucocutaneous candidiasis
Choice B. Tuberculoid Leprosy caused by overactive Th1
Choice C. Eczema caused by overactive Th2
Choice D Shingles caused by decrease in Th1
Choice E Lupus caused by overactive Th1
Clonal anergy is the inability of cells to proliferate. This is due to the absence of appropriate costimulatory signals or by this inhibitory signal _________.
A. IFN-gamma B. IL-17 C. CTLA-4 D. IL-22 E. IL-5
SZ
Ans. C CTLA-4
This is the only inhibitor listed
IFN-gamma helps stimulate macrophages. IL-22 creates epithelial barrier and IL-17 recruits neutrophils. IL-5 recruits eosinophils.
