45. Humoral Immune Response II Flashcards
A 61 year old man comes visits the doctor due recurrent bacterial infection. After blood test it is noted that he is severely low in the number of NK cells that he posses. Which Fc receptor is associated this cells activation?
A. FcgRI B. FcgRIIA C. FcgRIIIA D. FcgRIIB E. FceRI
RFA
ANS C. FcgRIIA - (CD16) is distributed on NK cells and is involved in Antibody dependent cytotoxicity
A. FcgRI- (CD64) is distributed on Macrophages,Neutrophils and eosinophils and is involved in activation of phagocytes
B FcgRIIA- (CD32) is distributed on Macrophages,Neutrophils, platelets and is involved in inefficient activation of phagocytes
D. FcgRIIB- is distributed on B cells, DC, Mast cells, neutrophils and macrophages and is involved in INHIBITION of B cells and reduction of inflammation
E. FceRI- is distributed on Mast cells, basophils eosinophils involved in activation(degranulation ) of mast cells and basophils
The CDC is creating a vaccines for a recent outbreak disease. The vaccines selected antigens from the microbe are used rather than the whole organism. During the process the vaccine is treated with formalin. Which vaccine could the CDC be making?
A. Cholera B.Hib C. Hep A. D. DTaP E. MMR
RFA
Ans. D. DTap- (Diphtheria, Tetanus, acellular Pertussis), is a acceular Toxoid vaccine meaning selected antigens are used not the whole organism it is also treated with formalin.
A. Cholera- has is a dead whole bacteria vaccine
B. Hib- (Haemophilus influenzae type B), is a conjugate vaccine these are also only selected antigens not the whole organism and are used for encapsulated bacteria. But these vaccines are not formalin treated
C. Hep A- is a whole killed virus vaccine
E. MMR- (Measles, Mumps, Rubella) is a live attenuated whole virus vaccine
You are doing a peds rotation in the high altitude mountainous region of East BumFuck. After performing the ‘scotch-tape’ test on the poor boy’s asshole you discover he has Enterobius, pinworms. Besides treating him with antiparasitics his natural humoral immunity will be activated. Which of the following receptors will be activated to fight the worms?
A. FcgRI B. FcERI C. FcGRIIIA D. FcRIIA E. FcRIIB
SZ
Ans. B FcERI
FcERI will activate eosinophils and kill helminths.
A. FcgRI activates phagocytosis in macrophages, neutrophils, and eosinophils.
C. FCRIIIA is ADCC for NK cells.
D. FcRIIA is for phagocytosis in macrophages, neutrophils, eosinophils, and platelets.
E. FcRIIB is for feedback inhibition of B cells, B lymphocytes, dendritic cells, mast cells, neutrophils, and macrophages.
A patient receives his flu vaccine this year by nasal mist spray, last year he received in via IM injection. Which of the following represent this years administration of the vaccine as opposed to last years?
A. Inactivated Whole Viral Vaccine v. Live Attenuated Vaccine
B. Killed Whole Bacterial Vaccine v. Live Attenuated
C. Live Attenuated v. Inactivated Whole Viral Vaccine
D. Acellular Vaccine v. Inactivated Whole Viral Vaccine
E. Recombinant Vaccine v. Inactive Whole Active Vaccine
SZ
Ans. C Live Attenuated v. Inactivated Whole Viral Vaccine
Flu-mist is the Live Attenuated form. The IM injection is an example of an Inactivated Whole Viral Vaccine.
Killed Whole Bacterial Vaccines are for cholera or plague. Acellular vaccines are for treating bacterial toxins (Diphteria, tetanus, acellular pertussis) or encapsulated bacteria (Hib, PCV13, Neisseria meningitidis). Recombinant vector vaccines are genetically engineered and not approved yet.
