25. Antigen Recon. in Adaptive Immune System

Question 1

A two year old boy is found to have a malfunctioning AIRE, what is a associated with this condition?

A.  Celiac Disease 
B. Hypoparathyroidism 
C. COPD 
D.  Graves Disease 
E.  CHD

RFA

Answer 1

Ans. B Hypoparathyroidism

AIRE is the “autoimmune regulator” expressed in the medulla of the thymus it is important in negative selection of T-cells if it is defective, autoimmune disease is the result. Such as:

Primary adrenocortical failure

Chronic mucocutaneous candidiasis

Question 2

A sample of B cells is taken from a patient it observed that the cell is being targeted by tositumomab. With this information you can eliminate which/what B cell lineage cell/cells ?

A. Pro-B
B. Pre-B
C. Immature-B
D. Mature-B
E. Memory Cell
F. Plasma Cell

RFA

Answer 2

Ans. A & F

Tositumomab is a monoclonal antibody that interact with CD 20
so do: rituximab, obinutuzumab, ibritumomab

Since the antibody is interacting with CD 20 it can be any type of B cell except for Pro-B and Plasma Cell, the first and last cells of the B-cell line lack CD20