11. Intro to Immunology 1 Cells and Organs of the Immune System

Question 1

In humans which of these would factor in increased immunogenicity?

A. BSA
B. D-amino Acids 
C.Alum
D. High Dose Antigens
E.Low Dose Antigens

RFA

Answer 1

ANS C.- Alum is a Adjuvant in humans it increase the persistence of an antigen and innate response

A. BSA- is a adjuvant in Mice not humans

B. D- Amino Acids cannot be processed and are poorly immunogenics

D & E High and Low Dose- you want Intermediate does not to high not to low

Question 2

Drew Peacock is a pathologist and has discovered a new disease that destroys CFU-GEMM. Which cell type would you expect not to be effected by this new disease?

A.Eosinphil
B.Neutrophil 
C.Monocyte
D. Dendritic cell
E. Plasma Cell
F. Megakaryoblast

RFA

Answer 2

Ans. E Plasma Cells- Plasma Cells are derived from B cells which along with T and NK cells derive from Common lymphoid progenitor using CFU-L

All other cells come from Common myeloid progenitor using CFU-GEMM. This then splits into Granulocyte/monocyte progenitor and Megakaryocyte/erythrocyte progenitor

Question 3

Which of the following is a true statement? (MG)

A. A hapten is both an antigen and immunogen.
B. A hapten is an antigen, but it is not an immunogen.
C. An immunogen is not an antigen or hapten.
D. An immunogen is a hapten, but not an antigen.

Answer 3

B. A hapten is an antigen, but it is not an immunogen.

Immunogens and haptens are two subsets of antigens.

Question 4

All white blood cells have which cluster of differentiation? (MG)

A. 45
B. 19
C. 4
D. 8

Answer 4

A. 45

All white blood cells have CD45

Question 5

Which of the following is the best route of immunization induced by systemic immunity?

A. Intravenous
B. Intraperitoneal
C. Subcutaneous
D. Oral 
E. Intragastrical  

SZ

Answer 5

Ans C. Subcutaneous

Slow release is important.

Subcutaneous> intraperitoneal> Intravenous> Intragastrical

Oral route is for local mucosal immunity only

Question 6

A child acquires an infection at daycare. She develops rhonchi, a fever of 101.6 F, and urticaria diffusely on her trunk. A few days after the symptoms develop a portion of the immune system is activated. Which of the following would be classified as a humoral component for this portion of the immune system?

A. Macrophage
B. Neutrophil
C. Lysozyme
D. Plasma Cells
E. Antibody 

SZ

Answer 6

Ans. E Antibody

A few days after symptoms appear the adaptive immune system is activated.

Choice A& B. Macrophages and neutrophils are cellular components of the innate system.
C. Lysozymes are humoral components of the innate system.
D. Plasma cells are cellular components of the adaptive system.