Hydatidiform Mole

Question 1

● Group of conditions in which tumors grow inside a
woman’s uterus.
● Pathologic proliferation of trophoblastic cells.

Answer 1

GESTATIONAL TROPHOBLASTIC DISEASE

Question 2

RISK FACTORS

Answer 2

● Younger than 20 and older than 35 years old
● Diet low in CHON & Vit. A
● Contraceptive pills
● Hx of molar pregnancy

Question 3

● Abnormal proliferation and then degeneration of
trophoblastic villi.
● Cells degenerate, filled w/ fluid and appear as clear
fluid-filled, grape-sized vesicles.

Answer 3

HYDATIDIFORM MOLE

Question 4

1.) The maternal chromosomes are lost
2.) The paternal chromosomes double up
3.) Results in a conceptus with 46 chromosomes but all derived from the father

Answer 4

Monospermic complete mole

Question 5

1.) The maternal chromosomes are lost
2.) Results in a conceptus with 46 chromosomes but all derived from the father

Answer 5

DISPERMIC COMPLETE MOLE

Question 6

Two sperm fertilize an egg, this results in a triploid conceptus with 69 chromosomes

Answer 6

Partial Mole

Question 7

EVACUATION OF THE TROPHOBLASTIC TISSUE

Answer 7

● Before evacuation, chest radiography, CT scan, or
MRI may be performed.

● CBC, coagulation status, and blood type and
screen or cross-matching procedures.

● The mole is usually removed by Vacuum Aspiration
followed by curettage.

● After tissue removal, IV oxytocin is given, to contract
the uterus.