APAS

Question 1

● An autoimmune disease characterized by the
production of antiphospholipid antibodies.
● Associated with pregnancy complications that
include:
○ Fetal loss
○ Fetal growth restriction
○ Preeclampsia
○ Thrombosis

Answer 1

ANTIPHOSPHOLIPID ANTIBODY SYNDROME (APAS)

Question 2

1.) DVT of the lower extremities
2.) Stroke

Answer 2

1.) Venous Event
2.) Arterial Event

Question 3

Clinical and laboratory
criteria without other
recognized autoimmune
disease.

Answer 3

Primary antiphospholipid Syndrome

Question 4

With other autoimmune
disorders such as SLE
(systemic lupus
erythematosus).

Answer 4

Secondary Antiphospholipid Syndrome

Question 5

RISK FACTORS

Answer 5

● Having an autoimmune condition, such as systemic
lupus erythematosus or Sjogren’s syndrome.

● Having certain infections, such as syphilis,
HIV/AIDS, hepatitis C or Lyme disease.

Question 6

● Preeclampsia prior to 34 weeks’, and severe
preeclampsia requiring premature delivery.

● Infertility and pregnancy complications such as
spontaneous abortions, prematurity, and stillbirths.

Answer 6

MATERNAL IMPLICATIONS

Question 7

● Fetal growth restriction

● Preterm delivery for maternal severe preeclampsia
or fetal growth restriction.

Answer 7

FETAL IMPLICATIONS

Question 8

INDICATIONS FOR TESTING FOR aPL ANTIBODIES

Answer 8

● Obstetric indications

● Unexplained fetal death or stillbirth

● Recurrent pregnancy loss (3 or more
spontaneous abortions with no more than 1 live
birth)

Question 9

1.) IgG or IgM antibodies present at moderate to high levels in the blood on 2 or more occasions at least 6 weeks apart.

2.) Are detected in the blood on 2 or more occasions at least 6 weeks apart. False-positive results from the VDRL
test.

Answer 9

1.) Anticardiolipin antibodies
2.) Lupus anticoagulant antibodies