Homeostasis Word Stimulants Flashcards
Homeostasis
Constant internal conditions
Physiological control system
Organisms functions independent to external environment
Improve survival chance
Conditions kept constant
Blood glucose concentration
Blood and tissue fluid pH and water potential
Core temperature
Blood glucose concentration
Cellular respiration
Maintains water potential
Blood and tissue fluid pH and water potential
Cells strink/expand
Core temperature
Fat - insulator
Optimum temperature and pH
Enzymes most active (sensitive - denature)
Rate of enzyme-catalysed reactions maximum
Metabolism of cells most efficient
Feedback Mechanisms
Self regulating system Information about system changes effects future changes 1. Optimum 2. Stimuli 3. Receptors 4. Coordinator 5. Effectors 6. Feedback
Stimuli
Deviation from optimum
Receptors
Detect deviation
Coordinator
Receives info from receptors
Sends instructions to effectors
Effectors
Bring about response
Return system to optimum
Feedback
Informs receptors of system changes
Caused by effectors
Negative feedback
Reverses direction of change towards stimulus
Maintains stability
Conditions fluctuate around optimum
Self adjusting
Eg Blood glucose (high - insulin; low - glucagon)
Positive feedback
Causes more and more change away from optimum
Reinforces original change
Does not maintain stability
Chain reaction develops - could run out of control&destroy itself - (negative feedback prevents)
Eg Damaged tissues - continuous platelets - blood clot (breaks chain reaction)
Eg Neurones - Na+ influx = increases Na+ permeability
Glycogen
Glucose store
Liver and muscle tissue
Hormones
First messenger molecules
Bind to receptors (proteins)
Receptors
Embedded in phospholipid biplayer of plasma membrane of target cells
Endocytosis
Hormone-substrate complex > Cytoplasm (target cells)
Insulin combines with receptor passage
Hormone-substrate complex > Cytoplasm (target cells) > Golgi apparatus > Cell Surface > Plasma membrane
Insulin/Receptor Golgi apparatus
Bud off portions of material (glucose carrier proteins)
Insulin/Receptor Plasma membrane
Increase no. of glucose carrier proteins
Uptake of glucose increases
Glucagon & Adrenaline combines with receptor passage
Activates Adenylate cyclase
Adenylate cyclase
ATP > cyclic AMP (cAMP)
cyclic AMP (cAMP)
Secondary messenger molecule
Activates glycogen phosphorylase (glycogen > glucose)
Insulin
Secreted by B cells of islets of Langerhan (pancreas)
Responds to high glucose conc (reduces conc)
Liver/Muscle Plasma membrane more permeable to glucose > more uptake
Glucose > glycogen
Glycogenesis
Insulin
Glucose > Glucogen
Glucogen synthase
Condensation
Glucogen synthase
Glucose > Glucogen