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DIT/Boards > HIV Drugs > Flashcards

HIV Drugs Flashcards

1
Q

-navir

A

Protease Inhibitors

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2
Q

-vir- in the middle

A

NNRTIs

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3
Q

Raltegravir Class

A

Integrase inhibitor

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4
Q

Enfuvirtide Class

A

Fusion inhibitor

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5
Q

Maraviroc Class

A

Fusion inhibitor

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6
Q 
Abacavir 
Didanosine 
Emtricitabine 
Lamivudine 
Tenofovir 
Zidovudine 
Class?
A

NRTIs

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7
Q

MOA of Protease Inhibitors

A

Inhibit HIV protease enzyme which cleaves precursor proteins
Virus unable to replicate

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8
Q

SE Lipodystrophy

A

Protease Inhibitors

Includes buffalo hump and increased truncal obesity

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9
Q

SE GI Intolerance

A

Protease Inhibitors

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10
Q

SE Inhibit Cytochrome P450

A

Protease Inhibitors (Ritonavir)

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11
Q

SE Hyperlipidemia/hypertriglyceridemia

A

Protease Inhibitors

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12
Q

SE Pancreatitis

A

Ritonavir

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13
Q

SE Nephrolithiasis

A

Indanavir Atasanavir

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14
Q

SE Increased bilirubin

A

Atasanavir

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15
Q

SE bone marrow suppression

A

Zidovudine

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16
Q

SE Pancreatitis and Peripheral Neuropathy

A

Didanosine

17
Q

SE Hepatic Steatosis

A

Didanosine

18
Q

SE Hypersensitivity Rxn

A

Abacavir (life threatening)

19
Q

SE Rash

A

NNRTIs

20
Q

SE Neuropsych Sx (nightmares, vivid dreams, dizzy, worsening depression)

A

Efavirenz

21
Q

SE false positive drug test to cannabinoids

A

Efavirenz

22
Q

SE tetratogenic

A

Efavirenz

23
Q

SE lactic acidosis

A

NRTIs

24
Q

SE megaloblastic anemia

A

Zidovudine

25
Q

SE DM hyperglycemia

A

Protease Inhibitors

26
Q

Given to pregnant women with HIV

A

Zidovudine

27
Q

Reigmen for occupational exposures

A

3 days

28
Q

MOA NNRTIs

A

Bind and inhibit HIV reverse transcriptase blocking DNA synthesis
Do not require phosphorylation

29
Q

Which drugs don’t require phosphorylation and are noncompetitive inhibitors?

A

NNRTIs

30
Q

MOA NRTIs

A

Competitively inhibit nucleotide binding to reverse transcriptase and terminate the DNA chain
Need to be phosphorylated

31
Q

Which drugs are competitive inhibitors and need to be phosphorylated for activation?

A

NRTIs

32
Q

MOA Inhibits HIV genome integration by reversibly inhibiting HIV integrase

A

Raltegravir

33
Q

MOA: Binds gp41 inhibiting viral dnetry

A

Enfuvirtide

34
Q

SE injection site reactions and increased risk fo bacterial pneumonia

A

Enfuvirtide

35
Q

MOA: binds to CCR5 surface receptor inhibiting interaction with gp120

A

Maraviroc

36
Q

Can only be used if patient has ALL R5 virus

A

Maraviroc

37
Q

Occupation exposure drug regimen

A

3 drugs for 4 weeks

DIT/Boards (22 decks)

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