HIV Drugs

Question 1

-navir

Answer 1

Protease Inhibitors

Question 2

-vir- in the middle

Answer 2

NNRTIs

Question 3

Raltegravir Class

Answer 3

Integrase inhibitor

Question 4

Enfuvirtide Class

Answer 4

Fusion inhibitor

Question 5

Maraviroc Class

Answer 5

Fusion inhibitor

Question 6

Abacavir 
Didanosine 
Emtricitabine 
Lamivudine 
Tenofovir 
Zidovudine 
Class?

Answer 6

NRTIs

Question 7

MOA of Protease Inhibitors

Answer 7

Inhibit HIV protease enzyme which cleaves precursor proteins
Virus unable to replicate

Question 8

SE Lipodystrophy

Answer 8

Protease Inhibitors

Includes buffalo hump and increased truncal obesity

Question 9

SE GI Intolerance

Answer 9

Protease Inhibitors

Question 10

SE Inhibit Cytochrome P450

Answer 10

Protease Inhibitors (Ritonavir)

Question 11

SE Hyperlipidemia/hypertriglyceridemia

Answer 11

Protease Inhibitors

Question 12

SE Pancreatitis

Answer 12

Ritonavir

Question 13

SE Nephrolithiasis

Answer 13

Indanavir Atasanavir

Question 14

SE Increased bilirubin

Answer 14

Atasanavir

Question 15

SE bone marrow suppression

Answer 15

Zidovudine

Question 16

SE Pancreatitis and Peripheral Neuropathy

Answer 16

Didanosine

Question 17

SE Hepatic Steatosis

Answer 17

Didanosine

Question 18

SE Hypersensitivity Rxn

Answer 18

Abacavir (life threatening)

Question 19

SE Rash

Answer 19

NNRTIs

Question 20

SE Neuropsych Sx (nightmares, vivid dreams, dizzy, worsening depression)

Answer 20

Efavirenz

Question 21

SE false positive drug test to cannabinoids

Answer 21

Efavirenz

Question 22

SE tetratogenic

Answer 22

Efavirenz

Question 23

SE lactic acidosis

Answer 23

NRTIs

Question 24

SE megaloblastic anemia

Answer 24

Zidovudine

Question 25

SE DM hyperglycemia

Answer 25

Protease Inhibitors

Question 26

Given to pregnant women with HIV

Answer 26

Zidovudine

Question 27

Reigmen for occupational exposures

Answer 27

3 days

Question 28

MOA NNRTIs

Answer 28

Bind and inhibit HIV reverse transcriptase blocking DNA synthesis Do not require phosphorylation

Question 29

Which drugs don't require phosphorylation and are noncompetitive inhibitors?

Answer 29

NNRTIs

Question 30

MOA NRTIs

Answer 30

Competitively inhibit nucleotide binding to reverse transcriptase and terminate the DNA chain Need to be phosphorylated

Question 31

Which drugs are competitive inhibitors and need to be phosphorylated for activation?

Answer 31

NRTIs

Question 32

MOA Inhibits HIV genome integration by reversibly inhibiting HIV integrase

Answer 32

Raltegravir

Question 33

MOA: Binds gp41 inhibiting viral dnetry

Answer 33

Enfuvirtide

Question 34

SE injection site reactions and increased risk fo bacterial pneumonia

Answer 34

Enfuvirtide

Question 35

MOA: binds to CCR5 surface receptor inhibiting interaction with gp120

Answer 35

Maraviroc

Question 36

Can only be used if patient has ALL R5 virus

Answer 36

Maraviroc

Question 37

Occupation exposure drug regimen

Answer 37

3 drugs for 4 weeks