HERPES FAMILY

Question 1

What kind of pathogen is Herpes?

Answer 1

Virus, LATENT FOR LIFE (once you have an infection it will remain dormant if your system for life)

Question 2

What infections are common in the Herpes family?

Answer 2

Roseola (HHV-6), Parvovirus (B19), Mono (Epstein Barr), Cytomegalovirus (CMV) Mononucleosis, Varicella

Question 3

How is Roseola spread?

Answer 3

respiratory droplets

Question 4

What is the pathogenesis of Roseola?

Answer 4

Replication in white blood cells and salivary galnds

Question 5

How does Roseola present?

Answer 5

-Acute onset high fever, possible febrile seizure
-72 hours later: onset of blanching pink maculopapular rash on trunk and spreading to face
*remains latent in immunocompromised lymphocytes and monocytes

Question 6

What is the treatment for Roseola?

Answer 6

Supportive care, anti-inflammatories

Question 7

How can Parvovirus be spread?

Answer 7

-Respiratory spread
-fomites
-mother to fetus
-transfusion of blood/blood products

*not contagious when rash appears

Question 8

What is the pathogenesis of Parvovirus?

Answer 8

-Parvovirus B19: hard to kill on surfaces
-not vaccine preventable
-resistant to heat/solvent detergent
-most infectious (5-10 days after exposure)
-incubation time of 7-10 days

Question 9

How does Parvovirus present?

Answer 9

Phase 1: febrile prodrome,SLAPPED CHEEK RASH

Phase 2: maculopapular rash on proximal extremities (fades to a classic lacy rash)

Phase 3: recurrences of lacy rash can last for moths

ADULTS: arthralgia with or without typical rash (common in fingers/wrists), 2-3 weeks after exposure

Complications: aplastic anemia, hydrops fetalis (fluid buildup and swelling in baby’s tissues), arthropathy

Question 10

How can Parvovirus be diagnosed?

Answer 10

-Patient history
-Serology (blood)
-IgM and IgG antibodies

Question 11

How is Parvovirus treated?

Answer 11

-Supportive care

*PREGNANT WOMEN SHOULD BE REFERRED TO OBGYN