HEME 3.82 Flashcards
what is a common reason people with renal failure may have anemia
erythropoitin is not being synthesized by the kidney
what are examples of chronic diseases that can cause anemia
TB, osteomyelitis, rheumatoid arthritis, Lupus, malignancies, and renal failures
what is acquired autoimmune hemolytic anemia (AIHA)
RBCs are destroyed faster then normal.
Instead of 120 days, it is as little as 20 Days.
hemolytic anemias can be ______ or ______
acquired, inherited
hereditary anemia are virtually all ______ in nature
hemolytic
what are the three major groups of disorders of inherited anemias
-Red cell membrane (hereditary spherocytosis, hereditary
elliptocytosis)
-Red cell enzymes (G6PD deficiency)
-hemoglobin molecules (sickle cell, thalassemias)
hereditary spherocytosis is caused by a variety of molecular defects in genes that code for (5)
- Specterin
- ankyrin
- band 3 protein
- protein 4.2
- other erythrocyte membrane proteins
what is the most helpful red cell index for hereditary spherocytosis
mean cell hemoglobin concentration (MCHC) which is routinely elevated
what does an elevated red cell distribution favor a diagnosis of HS
Red cell distribution width (normally between 11-15%)
hereditary elliptocytosis is caused by a veriety of molecular defects in _____ genes affected by hereditary shperocytosis
the same
what is the most common ENZYMATIC disorder of RBC in humans
G6PD deficiency
what is G6PD the only source of
NADPH
what does NADPH mainain
Glutathione
what are Heinz bodies
A cluster of denatured hemoglobin, only seen with a perticular stain where hemoglobin has been renduered unstable.
what are bite cells
thought to result from the processing of cells through the spleen and removal of heinz bodies
