HEME 3.81 Flashcards
decreased vitamin B12 levels produce RBCs that are ____________
Macrocytic (elevated MCV)
what is another term used to describe Vit. B12 deficient anemia
megaloblastic anemia
The metabolic pathway involved in replication of DNA are complex, and involve both ______ __ and ______
Vit. B12, Folate
why are cells in Vit. B12 deficient anemia macrocytic
RNA synthesis in not affected and so protein synthesis continues —-> the protein accumulates and the red cells get larger
what is a decrease in Vit. B12 due to Intrinsic factor (IF) called
pernicious anemia
Lack of IF is either on autoimmune attack on ___ or on the ______ ____ in the ______
IF, perietal cells, stomach
what are the three main reasons for Vit. B12 deficiencies
Lack of IF, Dietary, Total or partial gastrectomy or other stomach procedures
Does Folate require Intrinsic factor
No
what are four potential causes of Folate deficient anemia
- Poor nutrition
- increased requirements
- malabsorption
- Drugs
with anemia due to acute blood loss, the anemia is desctribed as
Normocytic
