HEME 2.61 Flashcards
what was the first oral direct thrombin inhibitor
Dabigatran (pradaxa), on the market in 2010
what is unique about Dabigatran (Pradaxa)
It does not require frequent blood tests for INR
when were direct X inhibitors introduced
released August 2011
what are some examples of Thrombolytics/fibrinolytics
- streptokinase
- urokinase
- synthetic tPA
- others
how do Thrombolytics/fibrinolytics function
rapidly lyse thrombi by catalyzing the formation of plasmin from plasminogen
when do thrombolytics work best
the sooner they are initiated from the onset of an event
what are the main classes of antiplatelets
- cyclooxygenase inhibitors (mainly aspirin)
- Thienophyidines (ADP Inhibitors)
- GP llb/llla inhibitors
how does aspirin work
inhibits the synthesis of TXA2, one of the substances that helps make the pltelets sticky and more likely to aggregate
what is the main drug associated with Thienopyridines (ADP inhibitors)
Clopidogrel (plavix)
what is an example of a GP llb/llla inhibitor
ABCiximab (ReoPro)
what is an example of a antifibrinolytics
Tranexamic acid
how does tranexamic acid function
activation of plasminogen to plasmin
how is tranexamic acid used in dentistry
In the form of 5% mouth rinse after extraction or surgery in patients with prolonged bleeding time
