Hallucination: DMT Nov 8th

Question 1

full name for DMT

Answer 1

Dimethyltryptamine

Question 2

street name for dimethyltryptamine

Answer 2

DMT, “businessman’s LSD” (could take a lunchbreak)

Question 3

DMT is more potent and therefore more effective than LSD

Answer 3

f more potent but not more effective

Question 4

how long onset? how long does it last?

Answer 4

15m onset, 1h duration

Question 5

is DMT natural

Answer 5

Alkaloid found in tree bark (mimosa hostilis)

Question 6

what family of drugs does it belong to

Answer 6

Tryptamine Family (tryptophan)

Question 7

what is tryptophan

Answer 7

molecule in turkey that makes you tired

Question 8

what is DMT structually similar to

Answer 8

Structurally similar to Serotonin (indole)

Question 9

for DMT does structure determine function

Answer 9

the structure Impliessimilartransportandenzymaticfunctions but doesnt functionally act like seretonin

Question 10

why is knowing the structure of the molecule important to understanding

Answer 10

important to understand how to facilitate or suppress activation

Question 11

what is DMT functionally similar to

Answer 11

psilocybin (due to receptors it targets)

Question 12

what does functional similarity help us understand

Answer 12

effects and similar mechanism of action

Question 13

what does structural similarity to seretonin help us understnad

Answer 13

how to facilitate or suppress activation

Question 14

T relationship between a chemical’s structure and biological activity

Answer 14

structure activity relationship

Question 15

according to the structure activity relationship Modification (of structure) allows for changes in … or …

Answer 15

effectiveness or potency

Question 16

is the structure the exact same as psilocybin

Answer 16

no slight difference leads to qualitativly extremely different experience

Question 17

is DMT and psilocybin Endemic to human body/function? (what system endogenous to us that is effected by these chemicals)

Answer 17

1. present in other animals

Question 18

where is analog chemical released

Answer 18

rat and rhesus monkey pineal gland but no evidene of such chemical in the human body

Question 19

support for endogenous function:… are naturally synthesized into Serotonin

Answer 19

Tryptamines

Question 20

2) … are naturally synthesized into Serotonin

Answer 20

Tryptamines

Question 21

Tryptamines are naturally synthesized into Serotonin supports endemic explaination but what is the problem with this

Answer 21

Enzyme responsible for DMT synthesis is found in humans, but… • Not in the brain (only in the body)

Question 22

the enzyme responsible for DMT synthesis might not be found in the brain but mRNA for enzyme has been found in the brain

Answer 22

f has not been found in brain

Question 23

what is the debate with endemic DMT?

Answer 23

Potential immune (stress) response signal?

Question 24

what is the speculation about the endogenous system of DMT

Answer 24

pineal gland and near-death experience (same elation that occurs in near death but why is it facilitative to have someone head toward the light from evolutionary perspective

Question 25

do we have a system set up for DMT

Answer 25

cant say with current findings

Question 26

what is the relationship between cancerous cells and DMT

Answer 26

Synthesis in (cancerous) human cells observed in laboratory settings (they have receptors for DMT in cancer cells)

Question 27

how does DMT influence immune system

Answer 27

facilitates the immune response (canbe used. on HIV? immunosuppression?)

Question 28

how is DMT effected by first pass

Answer 28

Greatly susceptible to enzymatic metabolism

Question 29

DMT Facilitation of immune response on ... receptors

Answer 29

endemic

Question 30

what is the problem with Facilitation of immune response on endemic receptors

Answer 30

treatment does not imply endemic origin

Question 31

what does DMT do thats similar to other hal?

Answer 31

agonist of seretonin 5HT2a

Question 32

what does DMT do thats different than other hal?

Answer 32

also effects dopamine

Question 33

since DMT effects dopaine is it associated with addictions?

Answer 33

no not d1 and d2 but sigma1 receptor

Question 34

what is dopamine sigma 1 receptor associated with

Answer 34

related to sensations

Question 35

where is the sigma 1 receptor found

Answer 35

the insula

Question 36

DMT is a SNDRA what does this mean

Answer 36

Serotonin-norepinephrine-dopamine releasing agent

Question 37

2 sites of action for dopamine?

Answer 37

amygdala and insula

Question 38

what does stage 1 of dopamine agonism from DMT cause (what effect?)

Answer 38

auditory hallucinations • crackling/extending tone that increases in volume and pitch

Question 39

what does stage 2 of dopamine agonism from DMT cause (what effect?)

Answer 39

Feels like being in a waiting room: suspense

Question 40

is the waiting room experienced physically and psychologically

Answer 40

physical fear response= increased heart rate | Psychological “startle” response (slow-motion, waiting, loss of time)

Question 41

what NT is in stage 3

Answer 41

seretonin

Question 42

where does seretonin stage 3 occur

Answer 42

PFC

Question 43

what 2 seretonin receptors

Answer 43

(5-HT2A, 5-HT2C)

Question 44

what do we know 5HT 2a is involved in from LSD

Answer 44

visual halluciations

Question 45

what is 5HT2c agonism effect

Answer 45

very specific illusion: “DMT Hyperspace” “Other side”= “Machine Elves”

Question 46

do they communicate with the machine elves

Answer 46

yes (not saying anything but I can understand them)

Question 47

T: presence of humanoid-like, half organic half technological beings

Answer 47

machine elves

Question 48

how do we usually expect DMT to be intook

Answer 48

synthesized tab

Question 49

T: version of powerdered DMT bark

Answer 49

snuff or Virola

Question 50

2 intake methods?

Answer 50

inhalation and injection

Question 51

can it be ingested

Answer 51

yes but MAO breaks all the active ingredients down

Question 52

where does MAO break down DMT when consumed orally

Answer 52

deactivates/breaks down DMT molecule in Liver

Question 53

how can you have a DMT trip orally then?

Answer 53

ayahuasca

Question 54

T: brew which includes plant-derived DMT, and | harmine/ harmaline/ tetrahydroharmine

Answer 54

ayahuasca

Question 55

Aya contains DMT and one of 3

Answer 55

haramine/ harmaline/ tetrahydroharamine (basicallys MAOI)

Question 56

is a DMT or Aya trip longer

Answer 56

aya = 3-6 hours

Question 57

aya has a similar experience to ... but more intense

Answer 57

psilocybin

Question 58

is aya more intense than LSD

Answer 58

no less then LSD but may include synasthesia

Question 59

side effect of aya?

Answer 59

intense vomiting/diarrhea

Question 60

T: intense vomiting/diarrhea

Answer 60

la purga

Question 61

what causes la purga

Answer 61

toxicity or from other things in the brew (stress response)

Question 62

is there any dietary restriction after taking aya due to effects on MAO enzymes

Answer 62

no only acts on MAO-A

Question 63

aya is a chemical

Answer 63

f DMT is aya is the brew

Question 64

LSD and mescaline does what to 5HT2A receptors

Answer 64

decreases

Question 65

what happens to 5HT2A with DMT

Answer 65

no decrease= no tolerance

Question 66

why is there no receptor down regulation with DMT

Answer 66

length of time receptor is occupied (LSD long duration of action DMT shorter acting= tolerance in response to how long receptor is activated) body removes from cell surface sp they can't be stimulated

Question 67

is there tolerance in DMT

Answer 67

might be acute or none

Question 68

what supports that there is no tolerance

Answer 68

lack of cross tolerance

Question 69

in DMT the ....may interfere with perception of tolerance

Answer 69

Cycle of “high”

Question 70

if you drop DMT then do LSD what will happen

Answer 70

you'll still have all the effects of LSD

Question 71

if you do LSD then drop DMT what will happen

Answer 71

you will not feel the DMT = DMT is less potent maybe also not strong enough to cause tolerance

Question 72

is seretonin system prone to down regulation

Answer 72

NO DOES NOT LIKE TO DOWNREG

Question 73

Any physical depednace with DMT

Answer 73

no

Question 74

and psychological dep with DMT

Answer 74

in question Ayahuasca presents negative side-effects and religious connotation but might find comfort with elves

Question 75

is there any DMT addiction potential

Answer 75

no

Question 76

T: Compared 40 ayahausca-sect adolescence and 40 age-, sex-, and education- and psychiatric symptomatology-matched controls

Answer 76

the Hoasca Project

Question 77

what were the results of the Hoasca project

Answer 77

Ayahuasca-sect adolescence had 7x lower incidence of | anxiety, body dysmorphism, and attention problems

Question 78

Low frequencies of psychiatric symptoms detected among adolescents consuming ayahuasca within a religious context may reflect a protective effect due to ...

Answer 78

their religious affiliation (safe within a certain connotation)

Question 79

DMT has therepudic uses in what type of therapy

Answer 79

Insight oriented psychotherapy

Question 80

what areas of the brain does aya trigger

Answer 80

amygdala and PFC and insula

Question 81

T: perceive reason and make decision

Answer 81

PFC

Question 82

T: storehouse for early emotional memories

Answer 82

amygdala

Question 83

T: bridge between emotional impulses and decision= where healing states generated making

Answer 83

Insula

Question 84

why are traumas rooted in our brains

Answer 84

patterns in connections and reinforced by neural networks

Question 85

how does ayauwaska effect ingrained patterns

Answer 85

hyperactivates entire brain region where we store and process emotional memory = enables conscious part of brain to override old patterns allowing new connections

Question 86

schematizing

Answer 86

retell stories again and again

Question 87

what do they usually give when people are retelling their stories

Answer 87

repynolol = blood pressure reducer

Question 88

what is the point of giving people repynolol when telling traumatic stories

Answer 88

stunts emotion component allows them to cognitively asses the situation

Question 89

3 thing DMT is used to treat through its cognitive and behavioural restructuring

Answer 89

PTSD, phobia, anxiety

Question 90

is using DMT for treatment meant to cognitively or behaviourally restructure

Answer 90

both

Question 91

T: cognitive restructuring based on logic

Answer 91

rationalization

Question 92

2 thought DMT treats through providing therepudic insight

Answer 92

depression and addiction (remove Fears, beliefs, motives, desires that they were at fault are are still unsafe)

Question 93

what the difference between affect and emotions

Answer 93

emotions is subjective affect is approach avoid= motivational

Question 94

emotions/cognitions: which part of brain that DMT effects

Answer 94

insula

Question 95

Affect - negative which part of brain that DMT effects

Answer 95

amygdala

Question 96

DMT allows one to not experience the hard emotions of trauma

Answer 96

f do feel then do to amygdala but decouples it from emotions and Elicits multiplicity of perspectives/perceptions

Question 97

DMT Hyperactivation allows for ... synapse to form which allows for New/learned interpretation generally positive

Answer 97

Hebbian