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haematology Flashcards

1
Q

management of sickle cell anaemia

A

hydroxycarbamide

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2
Q

what kind of anaemia can phenytoin cause

A

aplastic anaemia

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3
Q

what transfusion has the highest risk of bacterial contamination

A

platelets

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4
Q

investigation for definitive diagnosis of sickle cell disease

A

Hb electrophoresis

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5
Q

what is most common inherited thrombophilia

A

factor V leiden

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6
Q

what is factor V leiden

A

activated C protein resistance

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7
Q

lifespan of a platelet

A

7-10 days

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8
Q

lifespan of a RBC

A

120 days

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9
Q

if someone has heavy periods what is most likely causing their anaemia

A

iron deficiency

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10
Q

if Ann Arbor staging IIIB what does the B stand for

A

that they are experiencing B symptoms

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11
Q

what is the inheritance pattern of congenital sideroblastic anaemia

A

X linked recessive

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12
Q

virus making you more susceptible to Burkitt lymphoma

A

Epstein Barr virus

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13
Q

what haemoglobin genes in milk sickle cells

A

Hb SC

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14
Q

what is maximum dose of rivaroxaban

A

20mg

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15
Q

someone on maximum dose of DOAC and gets another DVT what is treatment

A

warfarin

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16
Q

nucleated red cells, left shift and basophilic vacuolated lymphoma cells
is what

A

Burkitt lymphoma

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17
Q

starry sky appearance on bone marrow biopsy

A

burkitt lymphoma

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18
Q

lymphocyte count in chronic lymphocytic leukaemia

A

raised

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19
Q

platelet count in chronic myeloid leukaemia

A

raised

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20
Q

what is thrombocytosis

A

raised platelet count

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21
Q

BP in transfusion related acute lung injury

A

hypotensive

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22
Q

BP in transfusion associated circulatory overload

A

hypertension

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23
Q

what lymph node is ovarian cancer most likely to spread to

A

para aortic lymph nodes

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24
Q

how long is treatment for a provoked DVT e.g. recent surgery

25
how long is treatment for an unprovoked DVT
6 months
26
what is the transfusion threshold
70 g/L
27
treatment for post thrombotic syndrome
compression stockings
28
what autoimmune haemolytic anaemia is associated with CLL
warm
29
what is cold autoimmune haemolytic anaemia associated with
- lymphoma - mycoplasma - EBV
30
what is most common type of Hodgkins lymphoma
nodular sclerosing
31
reticulocyte count in aplastic crisis
reduced
32
reticulocyte in sequestrian crisis
increased
33
what is caused by JAK2 mutation
polycythaemia vera
34
itching worse with heat, peptic ulcer, headache
polycythaemia vera
35
management of polycythaemia vera
hydroxycobalamin aspirin
36
what leukaemia has increased bands
CML
37
most common cause of neutropenic sepsis
staph epidermidis
38
is symmetrical lymphadenopathy more likely to be Hodgkins or non-hodgkins
non Hodgkins
39
investigation to confirm diagnosis of multiple myeloma
serum protein electrophoresis - M protein
40
painful lymphadenopathy when drinking alcohol is typical of
Hodgkins lymphoma
41
turners syndrome is associated with
haemophilia A
42
reticulocyte count is
percentage of total number of red blood cells in your blood
43
high reticulocyte count
anaemia due to RBC being destroyed bleeding blood disorder tumour
44
what cells are seen in coeliac disease
target cells Howell jolly bodies
45
what can myelodysplasia progress to
acute myeloid leukaemia
46
tear drop poikilocytes suggest
myelofibrosis
47
low IgA transfusion related complication
anaphylactic reaction
48
management of von willebrand disease
desmopressin
49
use of nitrous oxide is known to deplete what
B12 reserves
50
investigation for myelofibrosis
dry tap on bone marrow aspiration
51
investigations for tumour lysis syndrome
ECG U&E - potassium and phosphate raised calcium - low uric acid - low
52
blood transfusion patient presenting with fever, hypotension and anxiety is likely to be
acute haemolytic transfusion reaction
53
what is most concerning sign in transfusion reaction
hypotension - indicates anaphylaxis and TRALI
54
when do you give vit K if patient on warfarin
when their INR >8
55
what cells seen on blood film in patient with CKD
burr cells
56
what leukaemia causes massive splenomegaly
CML
57
what cells in CLL
smudge cells
58
who are most likely to get thalassaemia
those of mediterranean origin
59
complication of CLL
diffuse large B cell lymphoma - Richter transformation

finals (25 decks)

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