haematology Flashcards
management of sickle cell anaemia
hydroxycarbamide
what kind of anaemia can phenytoin cause
aplastic anaemia
what transfusion has the highest risk of bacterial contamination
platelets
investigation for definitive diagnosis of sickle cell disease
Hb electrophoresis
what is most common inherited thrombophilia
factor V leiden
what is factor V leiden
activated C protein resistance
lifespan of a platelet
7-10 days
lifespan of a RBC
120 days
if someone has heavy periods what is most likely causing their anaemia
iron deficiency
if Ann Arbor staging IIIB what does the B stand for
that they are experiencing B symptoms
what is the inheritance pattern of congenital sideroblastic anaemia
X linked recessive
virus making you more susceptible to Burkitt lymphoma
Epstein Barr virus
what haemoglobin genes in milk sickle cells
Hb SC
what is maximum dose of rivaroxaban
20mg
someone on maximum dose of DOAC and gets another DVT what is treatment
warfarin
nucleated red cells, left shift and basophilic vacuolated lymphoma cells
is what
Burkitt lymphoma
starry sky appearance on bone marrow biopsy
burkitt lymphoma
lymphocyte count in chronic lymphocytic leukaemia
raised
platelet count in chronic myeloid leukaemia
raised
what is thrombocytosis
raised platelet count
BP in transfusion related acute lung injury
hypotensive
BP in transfusion associated circulatory overload
hypertension
what lymph node is ovarian cancer most likely to spread to
para aortic lymph nodes
how long is treatment for a provoked DVT e.g. recent surgery
3 months
how long is treatment for an unprovoked DVT
6 months
what is the transfusion threshold
70 g/L
treatment for post thrombotic syndrome
compression stockings
what autoimmune haemolytic anaemia is associated with CLL
warm
what is cold autoimmune haemolytic anaemia associated with
- lymphoma
- mycoplasma
- EBV
what is most common type of Hodgkins lymphoma
nodular sclerosing
reticulocyte count in aplastic crisis
reduced
reticulocyte in sequestrian crisis
increased
what is caused by JAK2 mutation
polycythaemia vera
itching worse with heat, peptic ulcer, headache
polycythaemia vera
management of polycythaemia vera
hydroxycobalamin
aspirin
what leukaemia has increased bands
CML
most common cause of neutropenic sepsis
staph epidermidis
is symmetrical lymphadenopathy more likely to be Hodgkins or non-hodgkins
non Hodgkins
investigation to confirm diagnosis of multiple myeloma
serum protein electrophoresis - M protein
painful lymphadenopathy when drinking alcohol is typical of
Hodgkins lymphoma
turners syndrome is associated with
haemophilia A
reticulocyte count is
percentage of total number of red blood cells in your blood
high reticulocyte count
anaemia due to RBC being destroyed
bleeding
blood disorder
tumour
what cells are seen in coeliac disease
target cells
Howell jolly bodies
what can myelodysplasia progress to
acute myeloid leukaemia
tear drop poikilocytes suggest
myelofibrosis
low IgA transfusion related complication
anaphylactic reaction
management of von willebrand disease
desmopressin
use of nitrous oxide is known to deplete what
B12 reserves
investigation for myelofibrosis
dry tap on bone marrow aspiration
investigations for tumour lysis syndrome
ECG
U&E - potassium and phosphate raised
calcium - low
uric acid - low
blood transfusion patient presenting with fever, hypotension and anxiety is likely to be
acute haemolytic transfusion reaction
what is most concerning sign in transfusion reaction
hypotension
- indicates anaphylaxis and TRALI
when do you give vit K if patient on warfarin
when their INR >8
what cells seen on blood film in patient with CKD
burr cells
what leukaemia causes massive splenomegaly
CML
what cells in CLL
smudge cells
who are most likely to get thalassaemia
those of mediterranean origin
complication of CLL
diffuse large B cell lymphoma - Richter transformation
