endocrine Flashcards

1
Q

what is used in addition to metformin when patient has chronic heart failure

A

SGLT2 inhibitor
- empagliflozin

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2
Q

water deprivation results for nephrogenic diabetes insipidus

A

urine osmolality after fluid deprivation: low
urine osmolality after desmopressin: low

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3
Q

cause of nephrogenic diabetes inspidus

A

lithium

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4
Q

weight gain with hypertension, lethargy and proximal muscle weakness is suggestive of

A

Cushing syndrome

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5
Q

what is a risk factor for graves disease

A

smoking

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6
Q

what cancer is hashimotos associated with

A

MALT

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7
Q

results in Kallmanns syndrome

A

low FSH/LH
low testosterone

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8
Q

how do you manage primary hyperaldosteronism

A

spironolactone

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9
Q

which thyroid carcinoma is phaeochromocytoma associated with

A

medullary

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10
Q

what is the most common cause of primary hyperaldosteronism

A

bilateral adrenal hyperplasia

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11
Q

what are C-peptide levels in someone with T1DM

A

low

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12
Q

what does gliclazide do to C-peptide levels

A

elevates them

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13
Q

1st line treatment for prolactinoma

A

cabergoline (dopamine agonist)

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14
Q

what cardiac condition can hyperthyroidism lead to

A

high output cardiac failure

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15
Q

what is the 1st line test for acromegaly

A

IGF-1

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16
Q

if on a steroid what is the sick day rule

A

double the dose

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17
Q

can you give amitriptyline if a patient has benign prostatic hypertrophy

A

no
due to risk of urinary retention

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18
Q

what medication is used for acromegaly

A

ocreotide

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19
Q

hypertensive and hypokalaemia think

A

primary hyperaldosteronism

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20
Q

what is the dexamethasone suppression test of someone with Cushing syndrome caused by adrenal adenoma

A

corticosteroid - not suppressed
ACTH - suppressed

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21
Q

1st line investigation for patient with cushings

A

overnight dexamethasone suppression test

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22
Q

side effect of SGLT2 inhibitors

A

urinary tract infections

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23
Q

most common cause of hypopituitarism

A

pituitary adenoma

24
Q

how to differentiate between type 1 and type 2 diabetes using tests

A

C peptide
antibodies to glutamic acid decarboxylase

25
Q

treatment of hyperthyroidism in pregnancy

A

propylthiouracil

26
Q

ABG result of DKA

A

metabolic acidosis with partial respiratory compensation and increased anion gap

27
Q

what diabetic medication also induces weight loss

A

SLGT2 inhibitors

28
Q

how does splenectomy affect HbA1c

A

increases it

29
Q

does gliclazide cause weight gain or weight loss

A

weight gain

30
Q

glucocorticoid affect on neutrophils

A

neutrophilia (high neutrophil count)

31
Q

if insulin is given in hyperosmolar hyperglycaemia state what can it lead to

A

central pontine myelinolysis

32
Q

small testes, infertility, gynaecomastia, above average height and a lack of secondary characteristics =

A

klinefelter syndrome

33
Q

how long is carbimazole given in Graves disease

A

12-18 months

34
Q

ABG in cushings

A

hypokalaemia metabolic alkalosis

35
Q

what should be commenced in new cases of graves disease to control symptoms

A

propranolol

36
Q

what can mimic cushings disease

A

excess alcohol

37
Q

what is hashimottos thyroiditis associated with

A

thyroid lymphoma

38
Q

water deprivation test cranial DI

A

low urine osmolarity after fluid deprivation
high urine osmolality after desmopressin

39
Q

what diabetes medication is associated with necrotising fasciitis of genitalia

A

SGLT2 inhibitor

40
Q

painful goitre is likely to be

A

De Quervains tenosynovitis

41
Q

management of toxic multinodular goitre

A

radioactive iodine

42
Q

most common cause of secondary hypothyroidism

A

pituitary insufficiency

43
Q

diagnostic investigation for secondary hypothyroidism

A

MRI pituitary gland

44
Q

management of GI gastroparesis in diabetics

A

metoclopramide

45
Q

over replacement with thyroxine increases the risk of

A

osteoporosis

46
Q

T2DM treatment approach

A
  1. lifestyle
    • metformin
    • 2nd oral drug
  2. triple therapy - metformin + gliclazide + gliptin
    or metformin + pioglitazone + gliflozin
  3. insulin
47
Q

uptake of iodine in De Quervains

A

globally reduced uptake

48
Q

waddling gait can be a sign of

A

osteomalacia

49
Q

first line imaging for thyroid nodules

A

ultrasonography

50
Q

example of sulphonylurea

A

gliclazide

51
Q

a cause of primary hyperparathyroidism

A

parathyroid gland adenoma

52
Q

what alpha blocker is used in phaeochromocytoma

A

phenoxybenzamine

53
Q

what can be used in hyperaldosteronism with bilateral adrenal disease

A

amiloride

54
Q

drug management of acromegaly

A

somatostatin receptor ligand - ocreotide

55
Q

complication of DKA

A

cerebral oedema

56
Q

what is subclinical hyperthyroidism associated with

A

AF
osteoporosis
dementia

57
Q

medication that is useful for obese diabetic patients

A

DDP4-inhibitor
- sitagliptin