GLP-1 receptor analogues

Question 1

How do GLP-1 RAs work?

Answer 1

• Decrease appetite
• Slow gastric emptying
• Stimulate glucose secretion
• Suppress glucagon.
• Mimic normal GLP-1 hormone.
• Increase satiety.

Question 2

What does GLP-1 RA stand for?

Answer 2

Glucagon-like peptide receptor analogue.

Question 3

How does type 2 diabetes develop?

Answer 3

• Beta cells are overworked by prolonged high blood glucose levels.
• This leads to beta cell loss or impaired functioning, meaning the body may not be able to produce enough insulin to control blood glucose.
• This occurs in tandem to insulin resistance.

Question 4

What are the concerns?

Answer 4

• Malnutrition.
• Bowel obstructions and constipation that tapers away with time.