GI Infections 1 Flashcards
which bleeding/coagulation disorder marker is associated with indicating liver function?
prothrombin time (PT)
describe the biology hepatitis G virus
flavivirus (like HCV): enveloped ssRNA +
describe the biology of Hepatitis A
family: picornaviridae
naked, + ssRNA
HIGHLY STABLE
hepatitis C is endemic in what regions?
Egypt and mediterranean
different genotypes in different regions → different treatments
hepatitis ____ is part of the hepeviridae family
hepatitis E
very similar to hepatitis A
____ stools and dark urine are associated with the ______ stage of viral hepatitis
pale stools and dark urine = icteric (jaundice) face
describe the biology of Hepatitis E:
family: hepeviridae
naked ss RNA +
describe the replication of hepatitis A
- bind to receptor in the liver
- in the cytoplasm, the + sense RNA is trnalsted by ribosomes into a large polybprotein (group IV replication)
- polyprotein is cleaved into several polypeptides including a RNA dependent RNA polymerase
- RNA dependent RNA polymerase will synthesize both + and - sense RNA
- virus is released by exocytosis
describe the polymerase (_____ dependent _____ polymerase) used in hepatitis A virus
RNA dependent RNA polymerase
detection of anti HAV IgG indicates ________
previous infection (chronic infection is not that common with HAV infection )
fulminant hepatitis is more common with hepatitis ____
hepatitis B
pregnant women in endemic areas have a high prevalence of hepatitis ____ infection
hepatitis E
cleavage of the large polyprotein in HCV replication is done by ________
virion encoded protease or host cell protease
how is HAV most commonly transmitted?
fecal oral (contaminated food, water, etc) and is spread efficiently because virus is shed in the feces BEFORE symptoms arise
what type of vaccine is HAV?
inactivated; give to kids 2-18 y/o and those living or traveling to endemic areas
given in 2 doses, and a booster given 6-12 months after initial dose
what hepatitis has association with circulating LDL’s and VLDL’s
hepatitis C
Hepatitis ____ is from the family Picornavirdiae
Hepatitis A (non enveloped icosadheral ss RNA (+)
in hepatitis A and C, the _____ proteins are found on the 5’ end and ______ proteins are found in the 3’ end
structure proteins at the 5’
non structural protein at the 3’
hepatitis ____ has E1 and E2 membrane proteins
hepatitis C
other than hepatitis, what are other viruses that can cause liver inflammation?
- HSV (herpes)
- CMV
- EBV
- yellow fever virus
how long after ingestion of contaminated food can you expect to see symptoms of HAV infection?
3-4 weeks
hepatits A replicates in the _____
cytoplasm
there is NO vaccine for hepatitis _____
hepatitis C has no vaccine
the replication of HCV is similar to that of hepatitis ____
hepatitis A; both have group IV replication
virus enters and then the + sense RNA genome is translated by ribosomes to a large polyprotein which is then cleaved into peptides including RNA dependent RNA polymerase which then creates a - strand
high occurrence of hepatitis ____ in HIV patients with IVDU history
hepatitis C
which hepatitis virus is enveloped?
Hep C (and Hep G)
which hepatitis viruses can be transmitted fecal orally?
hepatitis A and E
what is the duration that differentiates between acute and chronic hepatitis?
6 months
hepatitis ____ is the most prevalent blood borne pathogen in the US
hepatitis C
describe the biology of hepatitis C
family: flaviviridae
ENVELOPED, ss RNA +
has E1 and E2 virus encoded membrane protein
acute/chronic infection is most commonly seen with HAV infection
acute
hepatitis C replicates in the _____
cytoplasm (like hepatitis A)
can HAV be spread from human to human via blood?
rarely
which hepatitis virus most commonly is associated with HCC and chronic infections
hepatitis C
C= chronic
C= hepatoCellular Carcinoma
