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PCM Exam 4 > GI Infections 1 > Flashcards

GI Infections 1 Flashcards

1
Q

which bleeding/coagulation disorder marker is associated with indicating liver function?

A

prothrombin time (PT)

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2
Q

describe the biology hepatitis G virus

A

flavivirus (like HCV): enveloped ssRNA +

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3
Q

describe the biology of Hepatitis A

A

family: picornaviridae
naked, + ssRNA
HIGHLY STABLE

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4
Q

hepatitis C is endemic in what regions?

A

Egypt and mediterranean

different genotypes in different regions → different treatments

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5
Q

hepatitis ____ is part of the hepeviridae family

A

hepatitis E

very similar to hepatitis A

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6
Q

____ stools and dark urine are associated with the ______ stage of viral hepatitis

A

pale stools and dark urine = icteric (jaundice) face

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7
Q

describe the biology of Hepatitis E:

A

family: hepeviridae

naked ss RNA +

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8
Q

describe the replication of hepatitis A

A
  • bind to receptor in the liver
  • in the cytoplasm, the + sense RNA is trnalsted by ribosomes into a large polybprotein (group IV replication)
  • polyprotein is cleaved into several polypeptides including a RNA dependent RNA polymerase
  • RNA dependent RNA polymerase will synthesize both + and - sense RNA
  • virus is released by exocytosis
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9
Q

describe the polymerase (_____ dependent _____ polymerase) used in hepatitis A virus

A

RNA dependent RNA polymerase

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10
Q

detection of anti HAV IgG indicates ________

A

previous infection (chronic infection is not that common with HAV infection )

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11
Q

fulminant hepatitis is more common with hepatitis ____

A

hepatitis B

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12
Q

pregnant women in endemic areas have a high prevalence of hepatitis ____ infection

A

hepatitis E

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13
Q

cleavage of the large polyprotein in HCV replication is done by ________

A

virion encoded protease or host cell protease

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14
Q

how is HAV most commonly transmitted?

A

fecal oral (contaminated food, water, etc) and is spread efficiently because virus is shed in the feces BEFORE symptoms arise

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15
Q

what type of vaccine is HAV?

A

inactivated; give to kids 2-18 y/o and those living or traveling to endemic areas
given in 2 doses, and a booster given 6-12 months after initial dose

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16
Q

what hepatitis has association with circulating LDL’s and VLDL’s

A

hepatitis C

17
Q

Hepatitis ____ is from the family Picornavirdiae

A

Hepatitis A (non enveloped icosadheral ss RNA (+)

18
Q

in hepatitis A and C, the _____ proteins are found on the 5’ end and ______ proteins are found in the 3’ end

A

structure proteins at the 5’

non structural protein at the 3’

19
Q

hepatitis ____ has E1 and E2 membrane proteins

A

hepatitis C

20
Q

other than hepatitis, what are other viruses that can cause liver inflammation?

A
  • HSV (herpes)
  • CMV
  • EBV
  • yellow fever virus
21
Q

how long after ingestion of contaminated food can you expect to see symptoms of HAV infection?

A

3-4 weeks

22
Q

hepatits A replicates in the _____

A

cytoplasm

23
Q

there is NO vaccine for hepatitis _____

A

hepatitis C has no vaccine

24
Q

the replication of HCV is similar to that of hepatitis ____

A

hepatitis A; both have group IV replication
virus enters and then the + sense RNA genome is translated by ribosomes to a large polyprotein which is then cleaved into peptides including RNA dependent RNA polymerase which then creates a - strand

25
Q

high occurrence of hepatitis ____ in HIV patients with IVDU history

A

hepatitis C

26
Q

which hepatitis virus is enveloped?

A

Hep C (and Hep G)

27
Q

which hepatitis viruses can be transmitted fecal orally?

A

hepatitis A and E

28
Q

what is the duration that differentiates between acute and chronic hepatitis?

A

6 months

29
Q

hepatitis ____ is the most prevalent blood borne pathogen in the US

A

hepatitis C

30
Q

describe the biology of hepatitis C

A

family: flaviviridae
ENVELOPED, ss RNA +
has E1 and E2 virus encoded membrane protein

31
Q

acute/chronic infection is most commonly seen with HAV infection

A

acute

32
Q

hepatitis C replicates in the _____

A

cytoplasm (like hepatitis A)

33
Q

can HAV be spread from human to human via blood?

A

rarely

34
Q

which hepatitis virus most commonly is associated with HCC and chronic infections

A

hepatitis C
C= chronic
C= hepatoCellular Carcinoma

PCM Exam 4 (44 decks)

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