Breast Pathology 2 Flashcards
BRCA___ mutation is relatively more common
BRCA1
Li Fraumeni syndrome is associated with a mutation in _____
p53
ER positive pathway of breast cancer is the most common and is associated with a germane BRCA___ mutation
BRCA2
the main cause of peas d’orange in _______ carcinoma of the breast is due to ______
peau d’orange occurs in inflammatory carcinoma and is due to lymphedema
breast cancer can spread to ____, ____ , _____ , or _____
lung, bones, liver, or adrenals
all breast carcinomas arise form cells in the ________
terminal duct lobular unit
in micro papillary DCIS (non comedo) is there a fibrovascular core?
no;
will see a fibrovascular core in the papillary type of intraductal carcinoma
BRCA1 mutations is associated with a ER _____ (+/-) breast cancer
ER negative
which breast carcinoma is associated with a mutation in E-cadherin?
lobular carcinoma in situ
Paget’s disease has cells that extend from ______ (breast carcinoma) via the ductal system via lactiferous sinuses and into the nipple skin
DCIS; look of underlying intraductal or invasive carcinoma
how does Paget’s disease present?
unilateral pruriti erthematous reputino with a scale crust; can be mistaken for eczema
is there basement membrane invasion in Paget’s disease?
NO;
describe the Paget cells on histology
- hyperchromatic cells with perinuclear halo
_______ stain can be used to strain for Paget cells
cytokeratin (epidermal)
lumina A ductal carcinoma is
ER:
HER2/neu:
ER +
HER2/neu -
more common
