Fungi II

Question 1

AIDS-Associated Mycoses:

Answer 1

Pneumocystis

Question 2

Candida albicans Dimorphism: Only in Disease States

Answer 2

Cycle:
Yeast
	“Good Form”
	 Sugar-fermenting
To
Pseudohyphae
To
“Hyphae”
	“Bad Form”
	Penetrates gut

Question 3

C. albicans Transition Triggers

Answer 3

To Hyphae

High Sugar or Starch Diet
Improper GI pH
Oral Antibiotics
Steroids
Contraceptives

Question 4

Candidiasis Transmission

Answer 4

Autoinnoculation:
GI system: change in conditions
Skin: breaches

Possible:
Sex
Childbirth
Surgery

Question 5

C. albicans Clinical Spectrum

Answer 5

GI System: Thrush (Discoloration, Hot, burning sensation), Enteritis
Skin: Diaper Rash(Poor ventilation / trapped moisture, Inflammation, scaling/flaking), Onychomycosis

Genitals (Yeast Infection): Monoliasis (Inflammation (incl. itching and swelling) , Vulvovaginal candidiasis; vaginitis (Purulent discharge)

Question 6

Candidiasis Treatment

Answer 6

Identify primary infection site

Pharmacy:
Azoles
Polyenes
Gut: AquaFlora

Question 7

Candidiasis Prevention & Control

Answer 7

Avoid behaviors that prompt mycelial transition

Curb transmission with infected:
No kissing
No sex

Question 8

Pneumocystis jiroveci: The Weirdo

Answer 8

Obligate parasite

No ergosterol + weak cell wall

Causes pneumonia (“PCP”)

Protozoan-like