Foundations in immunology 1-3 Flashcards
1
Q
Macrophage
A
Give off chemicals to restrict blood flow
Produce cytokines
2
Q
Complement
A
- lysis of microbes
- promote phagocytosis
- Stimulate inflammation
- Stimulate antibody production
3
Q
Non specific humoral response
A
- Growth inhibitor
- Enzyme inhibitor
- lysins
- Complement proteins - opsonisation
4
Q
Classical pathway
A
c3 then c5 convertase
Antibody
5
Q
Alternative pathway
A
c3 protein
6
Q
Lectin pathway
A
Absence of antibody
7
Q
HEV
A
Spaces do lymphocytes can escape and its a one way route
8
Q
What separates red and white pulp in spleen?
A
Marginal zone
9
Q
MHC
A
TCR recognises an antibody when bound to MHC
T helper stimulate B cell CD4
T cytoxic CD8
10
Q
MHC 1
A
CD8
11
Q
MHC2
A
CD4
12
Q
Antibody signalling part
A
Fc - constant region
Heavy and light chains
13
Q
Light chain
A
lamda and kappa = only 1 type present so identical
14
Q
Heavy chain
A
5 types - gama, omega, alpha, micro and E
15
Q
IgM
A
Fix complement and opsonisation
produced first
16
Q
IgG
A
Opsoniser
17
Q
IgE
A
Allergy
18
Q
IgA
A
Mucousal
19
Q
How can antibodies be flexible?
A
Position of epitope
