Forces Acting Across Membranes 3 Flashcards

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1
Q

Osmosis

A

Net movement of H2O from regions of high H2O concentration to regions of low H2O concentration

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2
Q

Diffusion

A

Net movement of solute from regions of high solute concentration to regions of low solute concentration

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3
Q

How is osmotic equilibrium maintained?

A

By the free movement of water

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4
Q

What will happen if a solution of different concentration is separated by a membrane permeable to H2O and the solute?

A

After a time there will be and equal concentration and an equal volume either side of the membrane

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5
Q

What will happen if a solution of different concentration is separated by a membrane permeable to only H2O?

A

After a time there will be equal concentrations either side of the membrane by different volumes

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6
Q

Osmotic pressure

A

The pressure required to prevent water movement

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7
Q

Why are cell membranes regarded as semi-permeable?

A

They are permeable to H2O and gases but some molecules in the ECF and ICF are unable to cross the membrane

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8
Q

Where do ions exchange readily?

A

Between the plasma and ISF

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9
Q

Why is the distribution of ions not equal across the ECF and ICF?

A

They do not penetrate the membrane

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10
Q

What determines the osmotic effect on H2O?

A

The number of solute particles

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11
Q

Osmolarity

A

Total number of particles in solution

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12
Q

What is the osmolarity of normal human plasma?

A

285mOsmol/L (often taken as 300) the same as within cells

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13
Q

What happens if there is a change in concentration of a solute that cannot cross the membrane?

A

Produces osmotic flux, causing a net movement of water n one direction or the other which changes the cell volume.

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14
Q

What is the volume of a cell at any time dependent on?

A

The concentration of non-penetrating solutes on either side of the membrane

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15
Q

What are non-penetrating particles of the ECF?

A

Na and Cl

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16
Q

What are non-penetrating particles of the ICF?

A

K and organic anions

17
Q

Tonicity

A

The number of non-penetrating particles in solution

18
Q

Isosmotic

A

A solution which has the same total number of solute particles as ECF

19
Q

Hypo-osmotic

A

Solutions with fewer total solute particles

20
Q

Hyper-osmotic

A

Solutions with greater number of total solute particles

21
Q

Isotonic

A

A solution which has the same number of non-penetrating solute particles as ECF

22
Q

Hypotonic

A

Solutions with fewer non-penetrating solute particles

23
Q

Hypertonic

A

Solutions with greater number of non-penetrating particles

24
Q

What determines tonicity?

A

Non-penetrating particles

25
Q

What determines osmolarity?

A

Penetrating and non-penetrating particles

26
Q

What is most of the 285mOsmol/L in the ECF attributed to?

A

The presence of Na and Cl which are non-penetrating particles therefor the tonicity of ECF is close to 285mOsmol/L

27
Q

What do plasma samples in the hospital give information about?

A

Osmolarity but not tonicity

28
Q

What is the best fluid to administer?

A

0.9% saline (150mM) as it is isotonic