Focal Segmental Glomerulonephritis

Question 1

What does Focal Segmental Glomerulonephritis cause?

Answer 1

Nephrotic syndrome and chronic kidney disease.

It generally presents in young adults.

Question 2

Who does Focal Segmental Glomerulonephritis typically present in?

Answer 2

Young adults.

Question 3

What are the possible causes of Focal Segmental Glomerulonephritis?

Answer 3

• idiopathic
• secondary to other renal pathology e.g. IgA nephropathy, reflux nephropathy
• HIV
• heroin
• Alport’s syndrome
• sickle-cell

Question 4

In who does focal segmental glomerulonephritis have a high recurrence rate?

Answer 4

High recurrence rate in renal transplants.

Question 5

What is the main investigation for focal segmental glomerulonephritis?

Answer 5

Renal biopsy

Question 6

What would you find on light microscopy of someone with focal segmental glomerulonephritis?

Answer 6

Focal and segmental sclerosis and hyalinosis

Question 7

What would you find on electron microscopy of someone with focal segmental glomerulonephritis?

Answer 7

Effacement of foot processes

Question 8

What is the management of focal segmental glomerulonephritis?

Answer 8

Steroids +/- immunosuppressants

Question 9

What chance of spontaneous remission is there with untreated focal segmental glomerulosclerosis?

Answer 9

untreated FSGS has a < 10% chance of spontaneous remission