First Aid pg 450-454 Neuro Flashcards

1
Q

Bilateral loss of pain and temperature sensation in upper limb?

A

Sphingomyelia,

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2
Q

Which part of the spinal cord affect in Sphingomyelia?

A

Most common at C8 –> T1

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3
Q

Intention tremor plus loss of pain and temp sensation in UL?

A

Chiari I malfomation - cerebellar tonisillar ectopia >3-5mm

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4
Q

Which fibers are destroyed in Syringomyelia?

A

crossed fibers in ant white commissure, spinothalamic tract

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5
Q

Which arches are responsible for the ant 2/3 tongue? Gen sens’n nerve? Nerve for taste?

A

1st and 2nd arch, Mandibular n (V3), Facial n (VII)

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6
Q

Which arches for the post 1/3 of tongue? N for gen sens’n and taste?

A

3rd and 4th arch, CN IX, root is CN X

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7
Q

Function of hyoglossus, genioglossus, and styloglossus?

A

Hyo - retracts and lower tongue
Genio - protrudes tongue
Stylo - pulls sides of tongue upwards

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8
Q

Which n innervates which m of tongue?

A

All muscles of tongue inn by CN XII, except palatoglossus, by CN X

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9
Q

Nissl staining stains what (what parts of neuron) and what molecular structure?

A

rER, so therefore only stains the body of neuron, not axon

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10
Q

What is Wallerian degeneration?

A

Degeneration distal to injury of an axon, and axonal retraction proximally

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11
Q

Where can axons regenerate?

A

Periph Nervous system

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12
Q

Which neuro cell type is responsible for K metabolism?

A

Astrocytes

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13
Q

marker of Astrocytes?

A

GFAP

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14
Q

Embryo origin of microglial cells?

A

mesodermal origin, from monocytes in Bone marrow

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15
Q

In HIV, what neurological reaction occurs in the CNS and with which cell type?

A

fomation of multinucleated giant cells from microglia

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16
Q

Which cells produce the myelin sheath in CNS and PNS?

A

CNS - oligodendrocytes

PNS - Schwann cells

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17
Q

What type of channels are seen at the nodes of Ranvier?

A

Na+ channels (where AP happens!)

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18
Q

Schwann cells are injured in which disease, causing ascending paralysis? Assoc with which microbe?

A

Guillan Barre syndrome, C. jejuni

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19
Q

Embryo origin of Schwann cells?

A

neural crest

20
Q

What is the difference in myelination between Schwann cells and oligodendrocytes? (other than location)

A

A Schwann cell can only myelinate one single PNS axon

An oligodendrocyte can myelinate several (about 30) CNS axons

21
Q

What neuro cell have a fried egg appearance histo wise?

A

Oligodendroglia

22
Q

What 3 diseases are associated with damage to oligodendroglia?

A

MS, PML (Progressive multifocal leukoencephalopathy), leukodystrophy

23
Q

Difference between C and Adelta fibers?

A

C - slow and unmyelinated (C student is slow) A - fast, myelinated)

24
Q

Where are meissner corpuscles located? What do they sense?

A

hairless skin, fine touch and position sense

25
Q

Where are pacinian corpuscles located? What do they sense?

A

vibration, pressure

26
Q

Where are Merkel discs located? What do they sense?

A

Pressure, deep touch, position sense

27
Q

Where are ruffini corpuscles?

A

finger tips, joints

28
Q

Location of synthesis of Ach? Inc /Dec in which disease?

A

Made at Basal nucleus - Inc in Parkinsons, Dec in Alzheimer, Huntingtons

29
Q

Location of synthesis of Dopamine?

A

Ventral tegmentum, SN(pars compacta)

30
Q

Inc/Dec Dopamine in which diseases?

A

Dec in depression, parkinson, - Inc in Schizophrenia, Huntington

31
Q

GABA made in ?

A

nucleus accumbens

32
Q

GABA dec in ?

A

Huntingtons, Anxiety

33
Q

Where is NE made?

A

Locus ceruleus

34
Q

NE inc/Dec in?

A

Inc = anxiety, dec = depression

35
Q

Serotonin made where?

A

Raphe nucleus

36
Q

Serotonin is inc/dec where?

A

Dec in Anxiety and depression, Inc in Par

37
Q

How does myelination affect n transmission characteristics?

A

have inc diam, and faster AP conduction

38
Q

3 parts to the BBB?

A

Tight junctions between nonfenestrated capillary endothelial cells, BM, Astrocyte foot processes

39
Q

What drugs can penetrate the blood brain barrier?

A

lipid soluble drugs

40
Q

Where is there a break in BBB to allow for secretion?

A

At the Hypothalamus for the secretion of ADH, Oxytocin and releasing factors.

41
Q

2 major inputs to HT not protected by BBB?

A
  1. OVLT (organum vasculosum of lamina terminalis, senses changes in Osmo
  2. Area postrema
42
Q

Which area of HT manages hunger? Stimulated/inhibited by?

A

Lateral area - Inc by Ghrelin, inhibited by leptin

43
Q

A cranipharyngioma of this area of the HT leads to hyperphagia, stimulated by what hormone?

A

VM - can be stimulated by leptin

44
Q

Which autonomic nervous system affects the cooling center?

A

PANS - bc when you’re resting and digesting, you want to be cool.

45
Q

Which nucleus causing cooling?

A

Ant - for A/C

46
Q

Which nucleus is responsible for heating?

A

Post - her butt is HOT

47
Q

Which nucleus is responsible for circadian rhythm?

A

Suprachiasmatic nucleus - You need to see light to have a good circadian rhythm