First aid pg 198 202 Immuno

Question 1

Function of lymph node follicle

Answer 1

Site of B cell localization and proliferation

Question 2

Cell types of medullary sinuses (2)

Answer 2

reticular cells and macrophages

Question 3

Cells present in Paracortex, not well developed in what disease

Answer 3

T cells, Di George’s

Question 4

What cells are in the PALS and follicles of the spleen

Answer 4

T cells, B cells

Question 5

Loss of splenic dysfunction leads to the decrease of three immune processes

Answer 5

decreased IgM, complement activation, C3b opsonization

Question 6

Asplenic patients are susceptible to which organisms

Answer 6

encapsulated - Strep Pneumo, H. influ, N meningitis, E coli, Salmonella, Klebsiella, Group B strep

Question 7

Thymus is derived from what embryonic structure

Answer 7

3rd pharyngeal pouch

Question 8

Cells of innate immunity

Answer 8

neutrophils, macrophages, monocytes, dendriditic cells, natural killer cells, complement

Question 9

Components of adaptive immunity

Answer 9

t cells, b cells, antibodies

Question 10

What do toll like receptors recognize?

Answer 10

PAMP - Pathogen associated molecular patterns

Question 11

HLA types for MHC I and MHC II

Answer 11

MHC I - HLA A, B, C MHC II - HLA DR, DP, DQ

Question 12

MHC I are expressed on which cells

Answer 12

nucleated cells

Question 13

MHC II are expressed on which cells

Answer 13

antigen presenting cells

Question 14

Associated proteins with MHC I/II

Answer 14

Beta 2 microglobulin, invariant chain

Question 15

Diseases assoc w. HLA A3

Answer 15

Hemochromatosis

Question 16

Diseases assoc w HLA B27

Answer 16

Psoriatic arthritis, Ankylosing spondylitis, IBS, Reactive arthritis

Question 17

Diseases assoc w HLA DQ2

Answer 17

Celiac disease

Question 18

Diseases assoc with HLA DR2

Answer 18

MS hay fever SLE Good Pasture

Question 19

Diseases assoc w HLA DR3

Answer 19

T1DB SLE Graves disease Hashimoto thyroiditis

Question 20

Diseases assoc w HLA DR4

Answer 20

RA, T1DB

Question 21

How do natural killer cells kill?

Answer 21

perforins, granzymes, Antibody dependent cell mediated cytotoxicity

Question 22

Positive selection - location, mech

Answer 22

Thymic cortex, T cells expressing T cell receptors capable of binding self MHC survive

Question 23

negative selection - location, mech

Answer 23

Medulla - T cells expressing t cell receptors with affinity for self antigen die (apoptosis)

Question 24

TH1 cells - secrete what, activated by

Answer 24

IFN gamma/ IFN gamma and IL 12

Question 25

TH1 cells - inhibited by

Answer 25

IL 4, IL 10

Question 26

TH2 cells - secrete what, activated by

Answer 26

IL 4, 5, 10, 13 / activated by IL 4

Question 27

TH2 cells - inhibited by

Answer 27

IFN gamma

Question 28

CD markers of T reg cells (3)

Answer 28

Cd 3, CD 4, CD 25