First Aid 333-336 Endo

Question 1

Increased risk of colorectal polyps and cancer in which endocrine cancer?

Answer 1

Acromegaly

Question 2

Mech of action of Pegvisomant? Is Tx for which disease?

Answer 2

GH-R antagonist, Acromegaly

Question 3

Which endocrine disorder is associated with saddle nose, prominent forehead, and small genitalia?

Answer 3

Laron syndrome

Question 4

Which drugs are associated with Nephrogenic DBI?

Answer 4

Lithium, Demeclocycline

Question 5

Tx for Nephrogenic DBI?

Answer 5

HCTZ, Indomethacin, Amiloride

Question 6

Tx for SIADH?

Answer 6

Fluid restriction
Salt tablets
IV hypertonic saline
diuretics
Conivaptan
Tolvaptan
Demeclocycline

Question 7

Failure to lactate, absent menstruation, cold intolerance

Answer 7

Sheehan syndrome

Question 8

unopposed secretion of GH and Epi can cause what endocrine disorder?

Answer 8

DB

Question 9

Why is there retinopathy/nephro/neuropathy with DB?

Answer 9

Due to nonenzymatic glycosylation in small vessels

Question 10

Osmotic damage in DB due to?

Answer 10

sorbital accumulation in organs with aldose reductase or dec/absent sorbitol DH

Question 11

What level of fasting plasma glucose is Dx for DB?

Answer 11

> 126 mg/dL

Question 12

What level for the 2 hr oral glucose tolerance test is Dx for DB?

Answer 12

> 200 mg/dL

Question 13

Why can you potentially see vomiting with insulin def?

Answer 13

inc lipolysis –> inc ketogenesis, ketonemia –> vomiting

Question 14

What type of metabolic issue with insulin def?

Answer 14

anion gap metabolic acidosis

Question 15

HLA # for T1DB?

Answer 15

HLA DR3 & DR4

Question 16

Autoimmune destruction of Beta cells due to?

Answer 16

glutamic acid decarboxylase Ab

Question 17

Sx of DB ketoacidosis?

Answer 17

Delirium, Kussmaul respirations, Abdom pain, n/v, dehydration, fruity breath odor

Question 18

Infectious complication of DB ketoacidosis?

Answer 18

Rhizopus - mucormycosis

Question 19

What is seen with elderly T2Db?

Answer 19

hyperglycemia induced dehydraion and inc serum osmo (Hyperosm hyperglycema non ketotic syndrome)

Question 20

Glucose level in non ketotic syndrome?

Answer 20

> 600 mg/dL

Question 21

Serum Osmo level in non ketotic syndrome?

Answer 21

> 320mOsm/kg

Question 22

Pt with migratory erythema, hypergylcemia, DVT, weight loss, depression?

Answer 22

Glucagonoma

Question 23

Whipple triad? in what Disease?

Answer 23

Low blood glucose
Sx of hypoglycemia - lethargy, syncope, diplopia
resolution of Sx with normalizing of glucose levels

Seen in Insulinoma

Question 24

10% of Insulinoma is associated with what, along with ZE syndrome?

Answer 24

MEN I

Question 25

Pt with DB or glucose intolerance, steatorrhea, gallstones ?

Answer 25

Somatostatinoma

Question 26

Cell type of carcinoid tumor?

Answer 26

neuroendocrine cells

Question 27

Why are sx of Carcinoid not seen if tumor is in GI?

Answer 27

5-HT goes through first pass metabolism

Question 28

Cardiac issue with carcinoid syndrome?

Answer 28

R side valvular disease - TR, Pulm stenosis

Question 29

Lab test in carcinoid

Answer 29

5-HIAA Hydroxyindoleacetic acid

Question 30

Dermatitis, diarrhea, and dementia seen in which endocrine disorder?

Answer 30

Carcinoid syndrome –> niacin Def

Question 31

Definitive Dx of ZE syndrome?

Answer 31

Gastrin levels stay elevated after admin of secretin (would dec Normally)