First Aid 333-336 Endo Flashcards
Increased risk of colorectal polyps and cancer in which endocrine cancer?
Acromegaly
Mech of action of Pegvisomant? Is Tx for which disease?
GH-R antagonist, Acromegaly
Which endocrine disorder is associated with saddle nose, prominent forehead, and small genitalia?
Laron syndrome
Which drugs are associated with Nephrogenic DBI?
Lithium, Demeclocycline
Tx for Nephrogenic DBI?
HCTZ, Indomethacin, Amiloride
Tx for SIADH?
Fluid restriction Salt tablets IV hypertonic saline diuretics Conivaptan Tolvaptan Demeclocycline
Failure to lactate, absent menstruation, cold intolerance
Sheehan syndrome
unopposed secretion of GH and Epi can cause what endocrine disorder?
DB
Why is there retinopathy/nephro/neuropathy with DB?
Due to nonenzymatic glycosylation in small vessels
Osmotic damage in DB due to?
sorbital accumulation in organs with aldose reductase or dec/absent sorbitol DH
What level of fasting plasma glucose is Dx for DB?
> 126 mg/dL
What level for the 2 hr oral glucose tolerance test is Dx for DB?
> 200 mg/dL
Why can you potentially see vomiting with insulin def?
inc lipolysis –> inc ketogenesis, ketonemia –> vomiting
What type of metabolic issue with insulin def?
anion gap metabolic acidosis
HLA # for T1DB?
HLA DR3 & DR4
Autoimmune destruction of Beta cells due to?
glutamic acid decarboxylase Ab
Sx of DB ketoacidosis?
Delirium, Kussmaul respirations, Abdom pain, n/v, dehydration, fruity breath odor
Infectious complication of DB ketoacidosis?
Rhizopus - mucormycosis
What is seen with elderly T2Db?
hyperglycemia induced dehydraion and inc serum osmo (Hyperosm hyperglycema non ketotic syndrome)
Glucose level in non ketotic syndrome?
> 600 mg/dL
Serum Osmo level in non ketotic syndrome?
> 320mOsm/kg
Pt with migratory erythema, hypergylcemia, DVT, weight loss, depression?
Glucagonoma
Whipple triad? in what Disease?
Low blood glucose
Sx of hypoglycemia - lethargy, syncope, diplopia
resolution of Sx with normalizing of glucose levels
Seen in Insulinoma
10% of Insulinoma is associated with what, along with ZE syndrome?
MEN I
Pt with DB or glucose intolerance, steatorrhea, gallstones ?
Somatostatinoma
Cell type of carcinoid tumor?
neuroendocrine cells
Why are sx of Carcinoid not seen if tumor is in GI?
5-HT goes through first pass metabolism
Cardiac issue with carcinoid syndrome?
R side valvular disease - TR, Pulm stenosis
Lab test in carcinoid
5-HIAA Hydroxyindoleacetic acid
Dermatitis, diarrhea, and dementia seen in which endocrine disorder?
Carcinoid syndrome –> niacin Def
Definitive Dx of ZE syndrome?
Gastrin levels stay elevated after admin of secretin (would dec Normally)
